Liver tissue engineering via hyperbranched polypyrrole scaffolds

被引:15
作者
Hatamzadeh, Maryam [1 ]
Sarvari, Raana [2 ,3 ]
Massoumi, Bakhshali [1 ]
Agbolaghi, Samira [4 ]
Samadian, Fatemeh [4 ]
机构
[1] Payame Noor Univ, Dept Chem, POB 19395-3697, Tehran, Iran
[2] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Stem Cell & Regenerat Med Inst, Tabriz, Iran
[4] Azarbaijan Shahid Madani Univ, Fac Engn, Chem Engn Dept, Tabriz, Iran
关键词
Electrospinning; human HEP G2 cells; polypyrrole; scaffold; BB'(2) TYPE MONOMERS; CONDUCTING POLYMERS; CHEMICAL-SYNTHESIS; FILMS; A(2); POLYADDITION;
D O I
10.1080/00914037.2019.1667800
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Synthesis of novel hyperbranched aliphatic polyester/polypyrrole (HAP-PPy) is reported to incorporate electroactive PPy units and biodegradable ester units into one macromolecular configuration. Electroactive nanofibers were prepared from HAP-PPy blended with polycaprolactone. HAP-PPy exhibited redox activity as detected by cyclic voltammetry, and thereby pyrrole units maintained their electroactivity even after incorporation into copolymer framework. Resulting scaffolds possessed porous structure (60-90 nm) with large surface area, electrical conductivity (0.003-0.008 S cm(-1)). These imitated natural microenvironment of extracellular matrix (ECM) to regulate cell attachment, proliferation, and differentiation.In vitrocytocompatibility studies indicated that nanofibers were nontoxic to human HEP G2 cells.
引用
收藏
页码:1112 / 1122
页数:11
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