Cyclophilin A: a key player for human disease

被引：363

作者：

Nigro, P. ^{[1
]}

Pompilio, G. ^{[1
]}

Capogrossi, M. C. ^{[2
]}

机构：

[1] Ctr Cardiol Monzino IRCCS, Lab Vasc Biol & Regenerat Med, I-20138 Milan, Italy

[2] Ist Dermopat Immacolata IRCCS, Lab Patol Vasc, Rome, Italy

来源：

CELL DEATH & DISEASE | 2013年 / 4卷

基金：

美国国家卫生研究院;

关键词：

CyPA; cardiovascular diseases; viral infections; neurodegeneration; cancer; rheumatoid arthritis; APOPTOSIS-INDUCING FACTOR; CELL-SURFACE EXPRESSION; CIS-TRANS-ISOMERASES; CYCLOSPORINE-A; OXIDATIVE STRESS; EXTRACELLULAR CYCLOPHILIN; IDENTIFIES CYCLOPHILIN; NUCLEAR TRANSLOCATION; SUPEROXIDE-DISMUTASE; RHEUMATOID-ARTHRITIS;

D O I：

10.1038/cddis.2013.410

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates protein folding and trafficking. Although CyPA was initially believed to function primarily as an intracellular protein, recent studies have revealed that it can be secreted by cells in response to inflammatory stimuli. Current research in animal models and humans has provided compelling evidences supporting the critical function of CyPA in several human diseases. This review discusses recently available data about CyPA in cardiovascular diseases, viral infections, neurodegeneration, cancer, rheumatoid arthritis, sepsis, asthma, periodontitis and aging. It is believed that further elucidations of the role of CyPA will provide a better understanding of the molecular mechanisms underlying these diseases and will help develop novel pharmacological therapies.

引用

页码：e888 / e888

页数：10

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