Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2

被引：20

作者：

Yuan, Meng ^{[1
]}

Wang, Yiquan ^{[2
]}

Lv, Huibin ^{[2
,3
]}

Tan, Timothy J. C. ^{[4
]}

Wilson, Ian A. ^{[1
,5
]}

Wu, Nicholas C. ^{[2
,4
,6
,7
]}

机构：

[1] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA

[2] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA

[3] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, HKU Pasteur Res Pole, Hong Kong, Peoples R China

[4] Univ Illinois, Ctr Biophys & Quantitat Biol, Urbana, IL 61801 USA

[5] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[6] Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA

[7] Univ Illinois, Carle Illinois Coll Med, Urbana, IL 61801 USA

来源：

CELL REPORTS | 2022年 / 41卷 / 07期

基金：

美国国家卫生研究院;

关键词：

allelic preference; broadly neutralizing; COVID-19; CP: Immunology; CP: Microbiology; data mining; public antibody; SARS-CoV-2; sequence analysis; variants of concern;

D O I：

10.1016/j.celrep.2022.111650

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concerns (VOCs) continue to emerge, cross-neutralizing antibody responses become key toward next-generation design of amore universal COVID-19 vaccine. By analyzing published data from the literature, we report here that the combination of germline genes IGHV2-5/IGLV2-14 represents a public antibody response to the receptor-binding domain (RBD) that potently cross-neutralizes a broad range of VOCs, including Omicron and its sub-lineages. Detailed molecular analysis shows that the complementarity-determining region H3 sequences of IGHV2-5/IGLV2-14-encoded RBD antibodies have a preferred length of 11 amino acids and a conserved HxIxxI motif. In addition, these antibodies have a strong allelic preference due to an allelic polymorphism at amino acid residue 54 of IGHV2-5, which is located at the paratope. These findings have important implications for understanding cross-neutralizing antibody responses to SARS-CoV-2 and its heterogenicity at the population level as well as the development of a universal COVID-19 vaccine.

引用

页数：10

共 51 条

[31]

Raybould Matthew I J, 2021, Bioinformatics, V37, P734, DOI 10.1093/bioinformatics/btaa739

[32] SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies [J].

Reincke, S. Momsen ;

Yuan, Meng ;

Kornau, Hans-Christian ;

Corman, Victor M. ;

van Hoof, Scott ;

Sanchez-Sendin, Elisa ;

Ramberger, Melanie ;

Yu, Wenli ;

Hua, Yuanzi ;

Tien, Henry ;

Schmidt, Marie Luisa ;

Schwarz, Tatjana ;

Jeworowski, Lara Maria ;

Brandl, Sarah E. ;

Rasmussen, Helle Foverskov ;

Homeyer, Marie A. ;

Stoffler, Laura ;

Barner, Martin ;

Kunkel, Desiree ;

Huo, Shufan ;

Horler, Johannes ;

von Wardenburg, Niels ;

Kroidl, Inge ;

Eser, Tabea M. ;

Wieser, Andreas ;

Geldmacher, Christof ;

Hoelscher, Michael ;

Ganzer, Hannes ;

Weiss, Gunter ;

Schmitz, Dietmar ;

Drosten, Christian ;

Pruss, Harald ;

Wilson, Ian A. ;

Kreye, Jakob .

SCIENCE, 2022, 375 (6582) :782-+

[33]

Robbiani Davide F, 2020, Nature, V584, P437, DOI [10.1101/2020.05.13.092619, 10.1038/s41586-020-2456-9]

[34]

Rodrigues Joao P G L M, 2018, F1000Res, V7, P1961, DOI 10.12688/f1000research.17456.1

[35] High frequency of shared clonotypes in human B cell receptor repertoires [J].

Soto, Cinque ;

Bombardi, Robin G. ;

Branchizio, Andre ;

Kose, Nurgun ;

Matta, Pranathi ;

Sevy, Alexander M. ;

Sinkovits, Robert S. ;

Gilchuk, Pavlo ;

Finn, Jessica A. ;

Crowe, James E., Jr. .

NATURE, 2019, 566 (7744) :398-+

[36] SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape [J].

Starr, Tyler N. ;

Czudnochowski, Nadine ;

Liu, Zhuoming ;

Zatta, Fabrizia ;

Park, Young-Jun ;

Addetia, Amin ;

Pinto, Dora ;

Beltramello, Martina ;

Hernandez, Patrick ;

Greaney, Allison J. ;

Marzi, Roberta ;

Glass, William G. ;

Zhang, Ivy ;

Dingens, Adam S. ;

Bowen, John E. ;

Tortorici, M. Alejandra ;

Walls, Alexandra C. ;

Wojcechowskyj, Jason A. ;

De Marco, Anna ;

Rosen, Laura E. ;

Zhou, Jiayi ;

Montiel-Ruiz, Martin ;

Kaiser, Hannah ;

Dillen, Josh R. ;

Tucker, Heather ;

Bassi, Jessica ;

Silacci-Fregni, Chiara ;

Housley, Michael P. ;

di Iulio, Julia ;

Lombardo, Gloria ;

Agostini, Maria ;

Sprugasci, Nicole ;

Culap, Katja ;

Jaconi, Stefano ;

Meury, Marcel ;

Dellota Jr, Exequiel ;

Abdelnabi, Rana ;

Foo, Shi-Yan Caroline ;

Cameroni, Elisabetta ;

Stumpf, Spencer ;

Croll, Tristan I. ;

Nix, Jay C. ;

Havenar-Daughton, Colin ;

Piccoli, Luca ;

Benigni, Fabio ;

Neyts, Johan ;

Telenti, Amalio ;

Lempp, Florian A. ;

Pizzuto, Matteo S. ;

Chodera, John D. .

NATURE, 2021, 597 (7874) :97-+

[37] Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms [J].

Tortorici, M. Alejandra ;

Beltramello, Martina ;

Lempp, Florian A. ;

Pinto, Dora ;

Dang, Ha, V ;

Rosen, Laura E. ;

McCallum, Matthew ;

Bowen, John ;

Minola, Andrea ;

Jaconi, Stefano ;

Zatta, Fabrizia ;

De Marco, Anna ;

Guarino, Barbara ;

Bianchi, Siro ;

Lauron, Elvin J. ;

Tucker, Heather ;

Zhou, Jiayi ;

Peter, Alessia ;

Havenar-Daughton, Colin ;

Wojcechowskyj, Jason A. ;

Case, James Brett ;

Chen, Rita E. ;

Kaiser, Hannah ;

Montiel-Ruiz, Martin ;

Meury, Marcel ;

Czudnochowski, Nadine ;

Spreafico, Roberto ;

Dillen, Josh ;

Ng, Cindy ;

Sprugasci, Nicole ;

Culap, Katja ;

Benigni, Fabio ;

Abdelnabi, Rana ;

Foo, Shi-Yan Caroline ;

Schmid, Michael A. ;

Cameroni, Elisabetta ;

Riva, Agostino ;

Gabrieli, Arianna ;

Galli, Massimo ;

Pizzuto, Matteo S. ;

Neyts, Johan ;

Diamond, Michael S. ;

Virgin, Herbert W. ;

Snell, Gyorgy ;

Corti, Davide ;

Fink, Katja ;

Veesler, David .

SCIENCE, 2020, 370 (6519) :950-+

[38] Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants [J].

Wang, Kang ;

Jia, Zijing ;

Bao, Linilin ;

Wang, Lei ;

Cao, Lei ;

Chi, Hang ;

Hu, Yaling ;

Li, Qianqian ;

Zhou, Yunjiao ;

Jiang, Yinan ;

Zhu, Qianhui ;

Deng, Yongqiang ;

Liu, Pan ;

Wang, Nan ;

Wang, Lin ;

Liu, Min ;

Li, Yurong ;

Zhu, Boling ;

Fan, Kaiyue ;

Fu, Wangjun ;

Yang, Peng ;

Pei, Xinran ;

Cui, Zhen ;

Qin, Lili ;

Ge, Pingju ;

Wu, Jiajing ;

Liu, Shuo ;

Chen, Yiding ;

Huang, Weijin ;

Wang, Qiao ;

Qin, Cheng-Feng ;

Wang, Youchun ;

Qin, Chuan ;

Wang, Xiangxi .

NATURE, 2022, 603 (7903) :919-+

[39] Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants [J].

Wang, Lingshu ;

Zhou, Tongqing ;

Zhang, Yi ;

Yang, Eun Sung ;

Schramm, Chaim A. ;

Shi, Wei ;

Pegu, Amarendra ;

Oloniniyi, Olamide K. ;

Henry, Amy R. ;

Darko, Samuel ;

Narpala, Sandeep R. ;

Hatcher, Christian ;

Martinez, David R. ;

Tsybovsky, Yaroslav ;

Phung, Emily ;

Abiona, Olubukola M. ;

Antia, Avan ;

Cale, Evan M. ;

Chang, Lauren A. ;

Choe, Misook ;

Corbett, Kizzmekia S. ;

Davis, Rachel L. ;

DiPiazza, Anthony T. ;

Gordon, Ingelise J. ;

Helmold-Hait, Sabrina ;

Hermanus, Tandile ;

Kgagudi, Prudence ;

Laboune, Farida ;

Leung, Kwanyee ;

Liu, Tracy ;

Mason, Rosemarie D. ;

Nazzari, Alexandra F. ;

Novik, Laura ;

O'Connell, Sarah ;

O'Dell, Sijy ;

Olia, Adam S. ;

Schmidt, Stephen D. ;

Stephens, Tyler ;

Stringham, Christopher D. ;

Talana, Chloe Adrienna ;

Teng, I-Ting ;

Wagner, Danielle A. ;

Widge, Alicia T. ;

Zhang, Baoshan ;

Roederer, Mario ;

Ledgerwood, Julie E. ;

Ruckwardt, Tracy J. ;

Gaudinski, Martin R. ;

Moore, Penny L. ;

Doria-Rose, Nicole A. .

SCIENCE, 2021, 373 (6556) :759-+

[40] A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2 [J].

Wang, Yiquan ;

Yuan, Meng ;

Lv, Huibin ;

Peng, Jian ;

Wilson, Ian A. ;

Wu, Nicholas C. .

IMMUNITY, 2022, 55 (06) :1105-+

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