Mitochondrial DNA polymorphisms in pathologically proven Parkinson's disease

被引：51
作者：
Bandmann, O
Sweeney, MG
Daniel, SE
Marsden, CD
Wood, NW
机构：
[1] UNIV LONDON,INST NEUROL,DEPT CLIN NEUROL,LONDON WC1N 3BG,ENGLAND
[2] NEUROL INST,PARKINSONS DIS SOC BRAIN BANK,LONDON,ENGLAND
来源：
JOURNAL OF NEUROLOGY | 1997年 / 244卷 / 04期
关键词：
Parkinson's disease; genetics; mitochondrial DNA;
D O I：
10.1007/s004150050082
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
To date, five single base pair changes of the mitochondrial DNA have been reported to occur either exclusively or with increased frequency in Caucasian patients with Parkinson's disease (PD) and it has been postulated that these mutations might be causally related to the observed inhibition of mitochondrial respiratory chain function in PD. To evaluate these findings, we analysed the frequency of all five polymorphisms in 100 cases of pathologically proven cases of PD. We were either unable to detect the previously described polymorphisms in our series or found them to be present with the same frequency among controls. Our data do not support the hypothesis of an involvement of the mitochondrial DNA in the pathogenesis of PD.
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页码：262 / 265
页数：4
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