Biomimetic composite scaffolds based mineralization of hydroxyapatite on electrospun calcium-containing poly(vinyl alcohol) nanofibers

被引：39

作者：

Chang, Wenkai ^{[1
]}

Mu, Xueyan ^{[1
]}

Zhu, Xiaoqun ^{[1
]}

Ma, Guiping ^{[1
,2
]}

Li, Chunguang ^{[1
]}

Xu, Fujian ^{[1
]}

Nie, Jun ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

[2] Beijing Univ Chem Technol, Changzhou Inst Adv Mat, Changzhou 213164, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2013年 / 33卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Electrospinning; Mineralization; Hydroxyapatite; Scaffolds; Bone tissue engineering; STEM-CELLS; IN-SITU; FIBERS; PHOSPHATE; CHITOSAN; NANOHYDROXYAPATITE; GROWTH; PRECIPITATION; NANOPARTICLES; REGENERATION;

D O I：

10.1016/j.msec.2013.06.023

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Nanocomposite materials consisting of polymer matrix and inorganic salts in the form of nanocrystals of hydroxyapatite (HA) are regarded as superior candidates for bone treatment. A biomimetic nanocomposite scaffold with HA formation on the electrospun poly(vinyl alcohol) (PVA) nanofibrous structure by employing a Ca-P alternate soaking method was developed in this work. The calcium-containing PVA nanofibers were prepared by adding calcium nitrate to the starting solution prior to electrospinning, and then mineralized by Ca-P treatment in incubation solution. With this rapid and effective procedure, a continuous biomimetic crystalline HA layer could be formed successfully without the need of a prior chemical modification of the substrate surface under very mild reaction conditions. Moreover, the HA formed with a relatively accelerated growth had a carbonated and poor crystalline structure, resembling biological apatite in the bone mineral. The introduction of calcium ions in nanofibers by electrospinning was a favorable approach to induce the deposition of calcium phosphate and improve the distribution, nucleation, and growth of crystalline HA layer on nanofibrous scaffolds. Bioactivity tests revealed that these mineralized PVA/HA composite scaffolds improved the biocompatibility. The porous polymer/HA composite scaffolds produced in the present study might have potential applications in bone tissue engineering. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：4369 / 4376

页数：8

共 40 条

[11] Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials [J].