Slow Ca2+ Sparks De-synchronize Ca2+ Release in Failing Cardiomyocytes: Evidence for Altered Ryanodine Receptor Distribution?

被引:0
|
作者
Louch, William [1 ]
Hake, Johan [2 ]
Mork, Halvor K. [1 ]
Hougen, Karina [1 ]
Skrbic, Biliana [1 ]
Lines, Glenn T. [2 ]
Tonnessen, Theis [1 ]
Sjaastad, Ivar [1 ]
Sejersted, Ole M. [1 ]
机构
[1] Univ Oslo, Expt Med Res Inst, Oslo, Norway
[2] Simula Rsch Lab, Oslo, Norway
关键词
Calcium; Sarcoplasmic reticulum; Heart failure;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
16425
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Quantifying Ca2+ release and inactivation of Ca2+ release in fast- and slow-twitch muscles
    Barclay, C. J.
    JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (23): : 6199 - 6212
  • [22] Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons
    Adasme, Tatiana
    Paula-Lima, Andrea
    Hidalgo, Cecilia
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 458 (01) : 57 - 62
  • [23] Effects of Sarcolemmal Background Ca2+ Entry and Sarcoplasmic Ca2+ Leak Currents on Electrophysiology and Ca2+ Transients in Human Ventricular Cardiomyocytes: A Computational Comparison
    Streiff, Molly E.
    Sachse, Frank B.
    FRONTIERS IN PHYSIOLOGY, 2022, 13
  • [24] EFFECT OF RYANODINE ON SARCOPLASMIC-RETICULUM CA2+ ACCUMULATION IN NONFAILING AND FAILING HUMAN MYOCARDIUM
    NIMER, LR
    NEEDLEMAN, DH
    HAMILTON, SL
    KRALL, J
    MOVSESIAN, MA
    CIRCULATION, 1995, 92 (09) : 2504 - 2510
  • [25] Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca2+ leak through ryanodine receptor in heart failure
    Yano, M
    Ono, K
    Ohkusa, T
    Suetsugu, M
    Kohno, M
    Hisaoka, T
    Kobayashi, S
    Hisamatsu, Y
    Yamamoto, T
    Kohno, M
    Noguchi, N
    Takasawa, S
    Okamoto, H
    Matsuzaki, M
    CIRCULATION, 2000, 102 (17) : 2131 - 2136
  • [26] Role of Ca2+, membrane excitability, and Ca2+ stores in failing muscle contraction with aging
    Payne, Anthony Michael
    Jimenez-Moreno, Ramon
    Wang, Zhong-Ming
    Messi, Maria Laura
    Delbono, Osvaldo
    EXPERIMENTAL GERONTOLOGY, 2009, 44 (04) : 261 - 273
  • [27] Altered interaction of FKBP12.6 with ryanodine receptor as a cause of abnormal Ca2+ release in heart failure
    Ono, K
    Yano, M
    Ohkusa, T
    Kohno, M
    Hisaoka, T
    Tanigawa, T
    Kobayashi, S
    Kohno, M
    Matsuzaki, M
    CARDIOVASCULAR RESEARCH, 2000, 48 (02) : 323 - 331
  • [28] Exocytosis, dependent on Ca2+ release from Ca2+ stores, is regulated by Ca2+ microdomains
    Low, Jiun T.
    Shukla, Alka
    Behrendorff, Natasha
    Thorn, Peter
    JOURNAL OF CELL SCIENCE, 2010, 123 (18) : 3201 - 3208
  • [29] Estimation of the fractional sarcoplasmic reticulum Ca2+ release in intact cardiomyocytes using integrated Ca2+ fluxes
    Bassani, Rosana A.
    Ricardo, Rafael A.
    Bassani, Jose W. M.
    GENERAL PHYSIOLOGY AND BIOPHYSICS, 2012, 31 (04) : 401 - 408
  • [30] Ca2+ Release through Ryanodine Receptors in the Sarcoplasmic Reticulum and Ca2+ Sequestration by the Mitochondria in Smooth Muscle Cells
    Yuji Imaizumi
    Yoshiaki Ohi
    Hisao Yamamura
    Kozo Morimura
    Katsuhiko Muraki
    Neurophysiology, 2003, 35 : 169 - 174