Dexamethasone Associated With Significantly Shorter Length of Hospital Stay Compared With a Prednisolone-Based Regimen in Pediatric Patients With Mild to Moderate Acute Asthma Exacerbations

被引：6
作者：
Bohannon, Kristin [1 ]
Machen, Ronda [1 ]
Ragsdale, Carolyn [1 ]
Padilla-Tolentino, Eimeira [1 ]
Cervenka, Patricia [1 ]
机构：
[1] Dell Childrens Med Ctr Cent Texas, 4900 Mueller Blvd, Austin, TX 78723 USA
来源：
CLINICAL PEDIATRICS | 2019年 / 58卷 / 05期
关键词：
corticosteroids; prednisone; methylprednisolone; length of stay; DOSE ORAL DEXAMETHASONE; RANDOMIZED-TRIAL; CHILDREN;
D O I：
10.1177/0009922819832091
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
A retrospective chart review was done to evaluate the efficacy of a course of dexamethasone for pediatric patients hospitalized with a mild to moderate acute asthma exacerbation compared with a prednisone-based regimen. Patients were identified based on International Classification of Diseases (ICD-9 and ICD-10) discharge diagnosis codes for asthma and cross-referenced with pharmacy dispense reports during the study period of June 2011 to January 2016. Baseline characteristics were similar among the 2 groups. The median length of hospital stay in the dexamethasone and prednisolone groups were 1.31 and 1.75 days, respectively, with a hazard ratio of 2.5 (95% confidence interval - 2.1-3.1), P < .001. After accounting for significant confounding variables, the difference in length of stay remained significantly longer in the prednisolone group with a hazard ratio of 1.8 (95% confidence interval = 1.4-2.3), P < .001. A course of dexamethasone is associated with a significantly shorter length of stay for mild to moderate asthma exacerbations compared with a prednisone-based regimen.
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收藏
页码：521 / 527
页数：7
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