Cancer-Associated Intermediate Conductance Ca2+-Activated K+ Channel KCa3.1

被引：49

作者：

Mohr, Corinna J. ^{[1
,2
,3
]}

Steudel, Friederike A. ^{[1
]}

Gross, Dominic ^{[1
]}

Ruth, Peter ^{[1
]}

Lo, Wing-Yee ^{[2
,3
]}

Hoppe, Reiner ^{[2
,3
]}

Schroth, Werner ^{[2
,3
]}

Brauch, Hiltrud ^{[2
,3
,4
]}

Huber, Stephan M. ^{[5
]}

Lukowski, Robert ^{[1
]}

机构：

[1] Univ Tubingen, Dept Pharmacol Toxicol & Clin Pharm, Inst Pharm, D-72076 Tubingen, Germany

[2] Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany

[3] Univ Tubingen, D-72076 Tubingen, Germany

[4] German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany

[5] Univ Tubingen, Dept Radiat Oncol, D-72076 Tubingen, Germany

来源：

CANCERS | 2019年 / 11卷 / 01期

关键词：

K(Ca)3.1; intermediate conductance calcium-activated K+ channel; BK; big conductance Ca2+- and voltage-activated K+ channels; TRAM-34; (1-[(2-chlorophenyl) diphenylmethyl]-pyrazole; 1-EBIO; 1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one; E2; 17; beta-estradiol; ACTIVATED POTASSIUM CHANNEL; CYCLE-DEPENDENT EXPRESSION; B-CELL DIFFERENTIATION; GARDOS CHANNEL; PROSTATE-CANCER; ION CHANNELS; CA CHANNEL; CISPLATIN SENSITIVITY; GLIOBLASTOMA CELLS; CARCINOMA-CELLS;

D O I：

10.3390/cancers11010109

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several tumor entities have been reported to overexpress K(Ca)3.1 potassium channels due to epigenetic, transcriptional, or post-translational modifications. By modulating membrane potential, cell volume, or Ca2+ signaling, K(Ca)3.1 has been proposed to exert pivotal oncogenic functions in tumorigenesis, malignant progression, metastasis, and therapy resistance. Moreover, K(Ca)3.1 is expressed by tumor-promoting stroma cells such as fibroblasts and the tumor vasculature suggesting a role of K(Ca)3.1 in the adaptation of the tumor microenvironment. Combined, this features K(Ca)3.1 as a candidate target for innovative anti-cancer therapy. However, immune cells also express K(Ca)3.1 thereby contributing to T cell activation. Thus, any strategy targeting K(Ca)3.1 in anti-cancer therapy may also modulate anti-tumor immune activity and/or immunosuppression. The present review article highlights the potential of K(Ca)3.1 as an anti-tumor target providing an overview of the current knowledge on its function in tumor pathogenesis with emphasis on vasculo- and angiogenesis as well as anti-cancer immune responses.

引用

页数：22

共 179 条

[41] Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells [J].