Immunomodulatory synergy by combining atorvastatin and rapamycin in the treatment of experimental autoimmune encephalomyelitis (EAE)

被引：20
作者：
Li, Zhenfei [1 ]
Chen, Liping [1 ]
Niu, Xiaoli [1 ]
Liu, Jia [1 ]
Ping, Man [1 ]
Li, Ru [1 ]
Xie, Xiaohua [1 ]
Guo, Li [1 ]
机构：
[1] Hebei Med Univ, Dept Neurol, Hosp 2, Shijiazhuang 050000, Hebei, Peoples R China
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 250卷 / 1-2期
关键词：
T regulatory cells; EAE; Multiple sclerosis; Combination therapy; ERK/MAPK; PLACEBO-CONTROLLED TRIAL; REMITTING MULTIPLE-SCLEROSIS; REGULATORY T-CELLS; DOUBLE-BLIND; GLATIRAMER ACETATE; T(H)17 CELLS; TH2; BIAS; MULTICENTER; INHIBITION; EXPRESSION;
D O I：
10.1016/j.jneuroim.2012.05.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Combination therapies are gaining momentum over monotherapies in the treatment of multiple sclerosis (MS). Suboptimal doses of atorvastatin and rapamycin prevented or reversed clinical and histologic experimental autoimmune encephalomyelitis (EAE). Secretion of proinflammatory Th1 and Th17 cytokines was reduced and Th2 and Treg cytokine secretion was increased in mice. Combination therapy promoted induction of Treg cells and attenuated the infiltration of inflammatory IL-17 cells in EAE. It appeared that rapamycin-reactivated ERK was blunted by addition of atorvastatin. Our results demonstrate that agents with different mechanisms of immune modulation can combine synergistically in treating CNS autoimmunity. (c) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：9 / 17
页数：9
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