Preparation and characterisation of chitosan microspheres for antioxidant delivery

被引：133

作者：

Kosaraju, Shantha L. ^{[1
]}

D'ath, Lynette ^{[1
]}

Lawrence, Andrew ^{[1
]}

机构：

[1] Food Sci Australia, Food Chem & Formulat Sci Grp, Werribee, Vic 3030, Australia

来源：

CARBOHYDRATE POLYMERS | 2006年 / 64卷 / 02期

关键词：

microspheres; chitosan; polyphenolic compounds; spraydrying; encapsulation;

D O I：

10.1016/j.carbpol.2005.11.027

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Encapsulation of olive leaf extract (OLE) in chitosan micropsheres was carried out by a spray-drying process. The interaction of polyphenolic compounds (PPCs) present in OLE within the polysaccharide matrix was studied using various physico-chemical techniques. Both the placebo and the OLE loaded microspheres were characterised by optical and scanning electron microscopy, particle size distribution analysis, Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The particles obtained after spray-drying were found to be spherical and had uniform particle size distribution patterns. FTIR and DSC indicate that there are interactions of polyphenolic compounds in OLE with the chitosan matrix. Further studies on encapsulation of OLE and its activity were analysed after the total hydrolysis of OLE loaded chitosan microspheres. The released polyphenolic compounds in OLE were estimated to confirm the activity of OLE loaded into the microspheres. The loading percent of polyphenolic compounds through encapsulation of OLE achieved was 27%. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：163 / 167

页数：5

共 13 条

[1]

BRANNONPEPPAS L, 1993, ACS SYM SER, V520, P42

[2]

CAN Z, 2004, J APPL POLYM SCI, V91, P659

[3] Optimizing formulation factors in preparing chitosan microparticles by spray-drying method [J].

Huang, YC ;

Chiang, CH ;

Yeh, MK .

JOURNAL OF MICROENCAPSULATION, 2003, 20 (02) :247-260

[4] Approach of uranium sorption mechanisms on chitosan and glutamate glucan by IR and C-13-NMR analysis [J].

JanssonCharrier, M ;

Saucedo, I ;

Guibal, E ;

LeCloirec, P .

REACTIVE & FUNCTIONAL POLYMERS, 1995, 27 (03) :209-221

[5]

MANNING AJ, 1976, Patent No. 2551891

[6]

MILES J, 1992, 2 WORKSH CONTR DEL C

[7]

Muzzarelli R. A., 1984, Carbohydr. Polym, V4, P137, DOI [10.1016/0144-8617(84)90020-1, DOI 10.1016/0144-8617(84)90020-1]

[8] PH-sensitive chitosan films for baker's yeast immobilization [J].

Öztop, HN ;

Saraydin, D ;

Çetinus, S .

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2002, 101 (03) :239-249

[9]

PEPPAS N, 1992, 2 WORKSH CONTR DEL C

[10] Study of the interactions between polyphenolic compounds and chitosan [J].

Popa, MI ;

Aelenei, N ;

Popa, VI ;

Andrei, D .

REACTIVE & FUNCTIONAL POLYMERS, 2000, 45 (01) :35-43

← 1 2 →