Acute behavioral and physiological effects of modafinil in drug abusers

被引:76
作者
Rush, CR [1 ]
Kelly, TH
Hays, LR
Baker, RW
Wooten, AF
机构
[1] Univ Kentucky, Dept Behav Sci, Lexington, KY 40536 USA
[2] Univ Kentucky, Dept Psychol, Lexington, KY 40506 USA
[3] Univ Kentucky, Dept Psychiat, Lexington, KY USA
[4] Eli Lilly Inc, Indianapolis, IN USA
来源
BEHAVIOURAL PHARMACOLOGY | 2002年 / 13卷 / 02期
关键词
modafinil; cocaine; stimulants; human; performance; abuse potential; self-reported drug effects; drug abuse;
D O I
10.1097/00008877-200203000-00002
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Modafinil, a novel stimulant, is effective in the treatment of excessive daytime sleepiness associated with narcolepsy. It is biochemically and pharmacologically distinct from prototypical stimulants such as D-amphetamine, cocaine, and methylphenidate. The present experiment was designed to assess the acute behavioral effects of oral modafinil, cocaine, and placebo in participants (n=9) with recent histories of cocaine use (i.e. positive urine for cocaine or benzoylecgonine during the initial screening interview). Drug effects were assessed with a battery of self-reported drug-effect questionnaires, performance measures, and physiological indices. Cocaine, but not modafinil, produced stimulant-like self-reported drug effects (e.g. increased ratings of High and Stimulated). Modafinil and cocaine dose-dependently increased heart rate and blood pressure. The results of the present study suggest that modafinil has minimal abuse potential, but should be viewed cautiously because of the relatively small sample size. Future studies should further characterize the abuse potential of modafinil using other behavioral arrangements, such as drug discrimination or drug self-administration. A full characterization of the abuse potential of modafinil will become important as the use of this drug increases. (C) 2002 Lippincott Williams Wilkins.
引用
收藏
页码:105 / 115
页数:11
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