Primary squamous cell carcinoma of the thyroid gland: A case report and review

被引:32
作者
Shrestha, Merica [1 ]
Sridhara, Shankar K. [2 ]
Leo, Leonard J. [3 ]
Coppit, George L., III [4 ]
Ehrhardt, Nicole M. [5 ]
机构
[1] Dwight D Eisenhower Army Med Ctr, Dept Med, Endocrinol Diabet & Metab Serv, Ft Gordon, GA 30905 USA
[2] Dwight D Eisenhower Army Med Ctr, Dept Surg, Otolaryngol Head & Neck Surg Serv, Ft Gordon, GA 30905 USA
[3] Walter Reed Natl Mil Med Ctr, Dept Pathol, Bethesda, MD USA
[4] Walter Reed Natl Mil Med Ctr, Dept Surg, Otolaryngol Head & Neck Surg Serv, Bethesda, MD USA
[5] Ft Belvoir Community Hosp, Dept Med, Endocrinol Diabet & Metab Serv, Ft Belvoir, VA USA
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2013年 / 35卷 / 10期
关键词
thyroid; squamous cell carcinoma; diagnosis; treatment; Hashimoto thyroiditis; EXPRESSION;
D O I
10.1002/hed.23152
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
BackgroundPrimary squamous cell carcinoma (SCC) of the thyroid gland is a rare malignancy that presents with advanced disease and poor prognosis. MethodsA 75-year-old woman with a history of Hashimoto thyroiditis presented with 6 months of dysphagia and stridor. Imaging revealed a thyroid mass invading the larynx. Primary SCC of the thyroid was diagnosed by histopathologic and immunohistochemical evaluation. Total thyroidectomy, total laryngectomy, bilateral modified neck dissection, and adjuvant radiotherapy (RT) were performed. Radiologic follow-up at 21 months demonstrated no disease and total length of survival was 31 months. ResultsDespite an aggressive T4aN0M0 tumor, survival in this case was more than double the median survival rate previously reported. Concomitant Hashimoto thyroiditis is rare and histopathologic and immunohistochemical evaluation is imperative for an accurate diagnosis. ConclusionThe case and literature reported here support that a thorough diagnostic workup of primary SCC of the thyroid with aggressive locoregional surgery and adjuvant RT may improve the length of survival. (c) 2012 Wiley Periodicals, Inc.(dagger)Head Neck 35: E299-E303, 2013
引用
收藏
页码:E299 / E303
页数:5
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