Combination of fenretinide and indole-3-carbinol results in synergistic cytotoxic activity inducing apoptosis against human breast cancer cells in vitro

被引：17

作者：

Cevatemre, Buse ^{[1
]}

Ari, Ferda ^{[1
]}

Sarimahmut, Mehmet ^{[1
]}

Oral, Arzu Y. ^{[2
]}

Dere, Egemen ^{[1
]}

Kacar, Omer ^{[3
]}

Adiguzel, Zelal ^{[3
]}

Acilan, Ceyda ^{[3
]}

Ulukaya, Engin ^{[2
]}

机构：

[1] Uludag Univ, Dept Biol, Fac Arts & Sci, Bursa, Turkey

[2] Uludag Univ, Dept Med Biochem, Sch Med, Bursa, Turkey

[3] TUBITAK Marmara Res Ctr, Genet Engn & Biotechnol Inst, Kocaeli, Turkey

来源：

ANTI-CANCER DRUGS | 2013年 / 24卷 / 06期

关键词：

3,3 '-diindolylmethane; breast cancer; chemotherapy; cytotoxicity; fenretinide (4-HPR); indole-3-carbinol; GENE-EXPRESSION; DOWN-REGULATION; OVARIAN-CANCER; CYCLE ARREST; GROWTH; 3,3'-DIINDOLYLMETHANE; DEATH; INDUCTION; 3,3-DIINDOLYLMETHANE; INHIBITION;

D O I：

10.1097/CAD.0b013e328360a921

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The outcome in patients with breast cancer is not satisfactory to date, although new chemotherapy regimens have been introduced in clinics. Therefore, novel approaches are required for better management of patients with breast cancer. In this study, we tested the cytotoxic activity of a new combination of fenretinide, a synthetic retinoid, with indole-3-carbinol, a natural product present in vegetables such as broccoli and cabbage, against MCF-7 (estrogen receptor-positive) and MDA-MB-231 (estrogen receptor-negative) cell lines. It has been found that the combination resulted in more powerful cytotoxic activity, by induction of apoptosis, compared with that when they were used singly. In conclusion, this novel combination warrants in-vivo experiments to elucidate its possible use in the treatment of breast cancer. (c) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：577 / 586

页数：10

共 41 条

[21] Cytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-α expression [J].

Leong, HY ;

Firestone, GL ;

Bjeldanes, LF .

CARCINOGENESIS, 2001, 22 (11) :1809-1817

[22] Cytotoxic responses to N-(4-hydroxyphenyl)retinamide in human pancreatic cancer cells [J].

Messner, Maria C. ;

Cabot, Myles C. .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2011, 68 (02) :477-487

[23] Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells [J].

Moiseeva, Elena P. ;

Almeida, Gabriela M. ;

Jones, George D. D. ;

Manson, Margaret M. .

MOLECULAR CANCER THERAPEUTICS, 2007, 6 (11) :3071-3079

[24] 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells [J].

Nguyen, Hanh H. ;

Lavrenov, Sergey N. ;

Sundar, Shyam N. ;

Nguyen, David H. H. ;

Tseng, Min ;

Marconett, Crystal N. ;

Kung, Jenny ;

Staub, Richard E. ;

Preobrazhenskaya, Maria N. ;

Bjeldanes, Leonard F. ;

Firestone, Gary L. .

CHEMICO-BIOLOGICAL INTERACTIONS, 2010, 186 (03) :255-266

[25] Gene expression profiling revealed survivin as a target of 3,3′-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells [J].

Rahman, K. M. Wahidur ;

Li, Yiwei ;

Wang, Zhiwei ;

Sarkar, Sarah H. ;

Sarkar, Fazlul H. .

CANCER RESEARCH, 2006, 66 (09) :4952-4960

[26]

Rahman KMW, 2005, CANCER RES, V65, P364

[27] Indole-3-carbinol (13C) induces apoptosis in ihmorigenic but not in nontumorigenic breast epithelial cells [J].

Rahman, KMW ;

Aranha, O ;

Sarkar, FH .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2003, 45 (01) :101-112

[28] 3,3′-Diindolylmethane inhibits migration and invasion of human cancer cells through combined suppression of ERK and AKT pathways [J].

Rajoria, Shilpi ;

Suriano, Robert ;

Wilson, Yushan Lisa ;

Schantz, Stimson P. ;

Moscatello, Augustine ;

Geliebter, Jan ;

Tiwari, Raj K. .

ONCOLOGY REPORTS, 2011, 25 (02) :491-497

[29] Phase III double-blind, placebo-controlled, prospective randomized trial of adjuvant tamoxifen vs. tamoxifen and fenretinide in postmenopausal women with positive receptors (EB193): an intergroup trial coordinated by the Eastern Cooperative Oncology Group [J].

Rao, Ruta D. ;

Cobleigh, Melody A. ;

Gray, Robert ;

Graham, Mark L., II ;

Norton, Larry ;

Martino, Silvana ;

Budd, George Thomas ;

Ingle, James N. ;

Wood, William C. .

MEDICAL ONCOLOGY, 2011, 28 :S39-S47

[30]

Roberson KM, 1997, CELL GROWTH DIFFER, V8, P101

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