Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy

被引：17

作者：

Xu, Xuefan ^{[1
]}

Zhang, Lei ^{[1
]}

Assanhou, Assogba G. ^{[1
,2
]}

Wang, Lu ^{[1
]}

Zhang, Yidi ^{[1
]}

Li, Wenyuan ^{[3
]}

Xue, Lingjing ^{[1
]}

Mo, Ran ^{[1
]}

Zhang, Can ^{[1
]}

机构：

[1] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China

[2] Univ Abomey Calavi, Fac Sci Sante, UFR Pharm, Cotonou, Benin

[3] Monash Univ, Fac Pharm & Pharmaceut Sci, Parkville, Vic 3052, Australia

来源：

RSC ADVANCES | 2015年 / 5卷 / 83期

基金：

中国国家自然科学基金;

关键词：

CELL UPTAKE; EFFICIENT; NANOPARTICLES; NANOCARRIERS; MICELLES; CLATHRIN; GLUTATHIONE; PEPTIDE; PROTEIN; ACID;

D O I：

10.1039/c5ra06445g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acid/redox dual-activated liposomes consisting of a synthetic functional lipid were developed to overcome the multiple barriers to the intravenous delivery of an anticancer drug from the injection site to the target site. The liposome exhibited tumor pH-promoted cellular uptake, endocytic pH-responsive endo-lysosomal escape and redox-triggered intracellular drug release, thereby yielding enhanced antitumor activity.

引用

页码：67803 / 67808

页数：6

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