Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp.

被引：35

作者：

Li, Rui ^{[1
]}

Shao, Chang-Lun ^{[1
]}

Qi, Xin ^{[1
]}

Li, Xiu-Bao ^{[2
]}

Li, Jing ^{[1
]}

Sun, Ling-Ling ^{[1
]}

Wang, Chang-Yun ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510000, Guangdong, Peoples R China

来源：

MARINE DRUGS | 2012年 / 10卷 / 07期

基金：

中国国家自然科学基金;

关键词：

soft coral; Sinularia sp; polyoxygenated sterols; cytotoxicity; SARCOPHYTON-INFUNDIBULIFORME; POLYHYDROXYLATED STEROIDS; CYTOTOXICITY ASSAY; BRINE SHRIMP; CONSTITUENTS;

D O I：

10.3390/md10071422

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical investigation of the ethanol extract of soft coral Sinularia sp. collected from the South China Sea led to the isolation of three new polyoxygenated sterols, (3S,23R,24S)-ergost-5-ene-3 beta,23 alpha,25-triol (1), (24S)-ergostane-6-acetate-3 beta,5 alpha,6 beta,25-tetraol (2), (24S)-ergostane-6-acetate-3 beta,6 beta,12 beta,25-tetraol (3) together with three known ones (4-6). The structures, including relative configurations of the new compounds (1-3), were elucidated by detailed analysis of spectroscopic data (IR, UV, NMR, MS) and by comparison with related reported compounds. The absolute configuration of 1 was further determined by modified Mosher's method. Compound 5 exhibited moderate cytotoxicity against K562 cell line with an IC50 value of 3.18 mu M, but also displayed strong lethality toward the brine shrimp Artemia salina with a LC50 value of 0.96 mu M.

引用

页码：1422 / 1432

页数：11

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