Relationship between the glutathione-responsive degradability of thiol-organosilica nanoparticles and the chemical structures

被引：14
作者：
Doura, Tomoshiro [1 ]
Nishio, Tadashi [1 ]
Tamanoi, Fuyuhiko [2 ]
Nakamura, Michihiro [1 ]
机构：
[1] Yamaguchi Univ, Dept Organ Anat & Nanomed, Grad Sch Med, Ube, Yamaguchi 7558505, Japan
[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
来源：
JOURNAL OF MATERIALS RESEARCH | 2019年 / 34卷 / 07期
关键词：
nanostructure; chemical synthesis; transmission electron microscopy (TEM); MESOPOROUS SILICA NANOPARTICLES; ONE-POT SYNTHESIS; CONTROLLED-RELEASE; BIOMEDICAL APPLICATIONS; DRUG-DELIVERY; IN-VITRO; NANOMATERIALS; SPECTROSCOPY; NANOCAPSULES; DIFFUSION;
D O I：
10.1557/jmr.2018.501
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Stimuli-responsive degradable silica nanoparticles (NPs) are active topics of nanomaterial research, because they are expected to be low health-risk nanocarriers capable of controlled release of drugs. Among various stimuli-responsive silica NPs, disulfide bond-containing NPs show degradability by glutathione reduced form (GSH). Here, we synthesized and characterized three kinds of thiol-organosilica NPs made from 3-mercaptopropyltrimethoxysilane (MPMS) and 3-mercaptopropyl(dimethoxy) methylsilane (MPDMS). MPMS NPs, MPDMS NPs, and MPMS-MPDMS hybrid NPs revealed that the abundance ratio of disulfide bonds to thiols increased with the increase in content rate of MPDMS in thiol-organosilica NPs. We also revealed that thiol-organosilica NPs, which have disulfide bonds, are GSH-responsive degradable silica NPs using an electron microscopy and Ellman's tests. Furthermore, we synthesized fluorescent MPMS-MPDMS NPs, including rhodamine B, and demonstrated the GSH-responsive release of dye from the NPs. These experiments indicate the potential of thiol-organosilica NPs, which have disulfide bonds as a GSH-responsive drug carrier.
引用
收藏
页码：1266 / 1278
页数：13
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