Molecularly Targeted Agents as Radiosensitizers in Cancer Therapy-Focus on Prostate Cancer

被引：34

作者：

Alcorn, Sara ^{[1
]}

Walker, Amanda J. ^{[1
]}

Gandhi, Nishant ^{[1
]}

Narang, Amol ^{[1
]}

Wild, Aaron T. ^{[1
]}

Hales, Russell K. ^{[1
]}

Herman, Joseph M. ^{[1
,2
]}

Song, Danny Y. ^{[1
,2
,3
]}

DeWeese, Theodore L. ^{[1
,2
,3
]}

Antonarakis, Emmanuel S. ^{[2
]}

Tran, Phuoc T. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21231 USA

[3] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21231 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 07期

关键词：

prostate cancer; radiotherapy; radiosensitizer; molecularly targeted agents; HSP90; inhibitors; POSITRON-EMISSION-TOMOGRAPHY; MEMBRANE ANTIGEN-EXPRESSION; RANDOMIZED PHASE-II; ANDROGEN DEPRIVATION THERAPY; SQUAMOUS-CELL CARCINOMA; HEAT-SHOCK-PROTEIN-90; INHIBITOR; 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN; CONTINUAL REASSESSMENT METHOD; TYROSINE KINASE INHIBITOR; ENDOTHELIAL GROWTH-FACTOR; DOSE-ESCALATION TRIAL;

D O I：

10.3390/ijms140714800

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As our understanding of the molecular pathways driving tumorigenesis improves and more druggable targets are identified, we have witnessed a concomitant increase in the development and production of novel molecularly targeted agents. Radiotherapy is commonly used in the treatment of various malignancies with a prominent role in the care of prostate cancer patients, and efforts to improve the therapeutic ratio of radiation by technologic and pharmacologic means have led to important advances in cancer care. One promising approach is to combine molecularly targeted systemic agents with radiotherapy to improve tumor response rates and likelihood of durable control. This review first explores the limitations of preclinical studies as well as barriers to successful implementation of clinical trials with radiosensitizers. Special considerations related to and recommendations for the design of preclinical studies and clinical trials involving molecularly targeted agents combined with radiotherapy are provided. We then apply these concepts by reviewing a representative set of targeted therapies that show promise as radiosensitizers in the treatment of prostate cancer.

引用

页码：14800 / 14832

页数：33

共 181 条

[1]

Abrams TJ, 2003, MOL CANCER THER, V2, P1011

[2]

AKNER G, 1992, EUR J CELL BIOL, V58, P356

[3] UPDATE OF DUTCH MULTICENTER DOSE-ESCALATION TRIAL OF RADIOTHERAPY FOR LOCALIZED PROSTATE CANCER [J].

Al-Mamgani, Abrahim ;

van Putten, Wim L. J. ;

Heemsbergen, Wilma D. ;

van Leenders, Geert J. L. H. ;

Slot, Annerie ;

Dielwart, Michel F. H. ;

Incrocci, Luca ;

Lebesque, Joos V. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2008, 72 (04) :980-988

[4] Expanding Treatment Options for Metastatic Prostate Cancer [J].

Antonarakis, Emmanuel S. ;

Eisenberger, Mario A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (21) :2055-2058

[5] Dasatinib combined with docetaxel for castration-resistant prostate cancer [J].

Araujo, John C. ;

Mathew, Paul ;

Armstrong, Andrew J. ;

Braud, Edward L. ;

Posadas, Edwin ;

Lonberg, Mathew ;

Gallick, Gary E. ;

Trudel, Geralyn C. ;

Paliwal, Prashni ;

Agrawal, Shruti ;

Logothetis, Christopher J. .

CANCER, 2012, 118 (01) :63-71

[6]

Armstrong A.J., MULTIMODALITY PHASE

[7] The Clinical Development of Molecularly Targeted Agents in Combination With Radiation Therapy: A Pharmaceutical Perspective [J].

Ataman, Ozlem U. ;

Sambrook, Sally J. ;

Wilks, Chris ;

Lloyd, Andrew ;

Taylor, Amanda E. ;

Wedge, Stephen R. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 84 (04) :E447-E454

[8]

Azria D, PHASE 1 TRIAL EVALUA

[9] Comparative Evaluation of Radiation Treatments for Clinically Localized Prostate Cancer: An Updated Systematic Review [J].

Bannuru, Raveendhara R. ;

Dvorak, Tomas ;

Obadan, Ndidiamaka ;

Yu, Winifred W. ;

Patel, Kamal ;

Chung, Mei ;

Ip, Stanley .

ANNALS OF INTERNAL MEDICINE, 2011, 155 (03) :171-+

[10] Pharmacokinetic Assessment of the Uptake of 16β-18F-Fluoro-5α-Dihydrotestosterone (FDHT) in Prostate Tumors as Measured by PET [J].

Beattie, Bradley J. ;

Smith-Jones, Peter M. ;

Jhanwar, Yuliya S. ;

Schoeder, Heiko ;

Schmidtlein, C. Ross ;

Morris, Michael J. ;

Zanzonico, Pat ;

Squire, Olivia ;

Meirelles, Gustavo S. P. ;

Finn, Ron ;

Namavari, Mohammad ;

Cai, Shangde ;

Scher, Howard I. ;

Larson, Steven M. ;

Humm, John L. .

JOURNAL OF NUCLEAR MEDICINE, 2010, 51 (02) :183-192

← 1 2 3 4 5 6 7 8 9 10 →