Catalytic sp3 C-H Oxidation of Peptides and Their Analogues by Radical Cation Salts: From Glycine Amides to Quinolines

被引：63

作者：

Jia, Xiaodong ^{[1
]}

Wang, Yaxin ^{[1
]}

Peng, Fangfang ^{[1
]}

Huo, Congde ^{[1
]}

Yu, Liangliang ^{[1
]}

Liu, Jing ^{[1
]}

Wang, Xicun ^{[1
]}

机构：

[1] Northwest Normal Univ, Key Lab Ecoenvironm Related Polymer Mat, Minist Educ, China & Gansu Key Lab Polymer Mat,Coll Chem & Che, Lanzhou 730070, Gansu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 18期

关键词：

DIELS-ALDER REACTION; AMINO-ACIDS; DERIVATIVES; FUNCTIONALIZATION; TETRAHYDROQUINOLINES; REARRANGEMENTS; ADDITIONS; ADJACENT; ANILINES; NITROGEN;

D O I：

10.1021/jo401018v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalytic alpha-sp(3) C-H oxidation of peptides and glycine amides was achieved under radical cation salt catalysis in the presence of O-2, producing a series of substituted quinolines. The scope of this reaction shows good functional group tolerance and high efficiency of the oxidative functionalization.

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收藏

页码：9450 / 9456

页数：7

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