Circling mouse, a spontaneous mutant in the inner ear

被引：21
作者：
Lee, JW
Ryoo, ZY
Lee, EJ
Hong, SH
Chung, WH
Lee, HT
Chung, KS
Kim, TY
Oh, YS
Suh, JG [1 ]
机构：
[1] Hallym Univ, Coll Med, Dept Med Genet, Chunchon 200702, South Korea
[2] Hallym Univ, Coll Med, Expt Anim Ctr, Chunchon 200702, South Korea
[3] Catholic Med Coll, Catholic Res Inst Med Sci, Lab Anim Ctr, Seoul 137701, South Korea
[4] Sungkyunkwan Univ, Samsung Med Ctr, Dept ORL HNS, Seoul 135710, South Korea
[5] Konkuk Univ, Coll Agr Anim & Life Sci, Seoul 143701, South Korea
[6] Catholic Med Coll, Catholic Res Inst Med Sci, Dept Dermatol, Seoul, South Korea
来源：
EXPERIMENTAL ANIMALS | 2002年 / 51卷 / 02期
关键词：
circling mouse; inner ear; organ of Corti;
D O I：
10.1538/expanim.51.167
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
A spontaneous mutant was established in the ICR mouse strain. The affected mice became hyperactive at about 7 days of age, and then showed circling behavior. The body weight decreased significantly 2 weeks after birth, and developmental defects were revealed in the middle ear, cochlea, cochlear nerve, and semicircular canal areas. The mutation was inherited by an autosomal single recessive gene and is referred to as cir.
引用
收藏
页码：167 / 171
页数：5
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