Preconditioning hypobaric hypoxia prevents anoxia-induced inhibition of generation of focal potentials in slices of olfactory cortex from rat brain

被引：5

作者：

Romanovskii, DY ^{[1
]}

Tyul'kova, EI ^{[1
]}

Samoilov, MO ^{[1
]}

机构：

[1] Russian Acad Sci, IP Pavlov Physiol Inst, St Petersburg 196140, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 132卷 / 06期

关键词：

hypobaric hypoxia; preconditioning; local potentials; brain slices;

D O I：

10.1023/A:1014546928677

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of in vivo exposure to hypobaric hypoxia of different depth on the resistance of neurons in brain slices to 10-min anoxia in vitro. Severe hypoxia simulating ascent to 11,000 in above sea level potentiated the adverse effect of 10-min anoxia and caused profound suppression of synaptic transmission. Moderate preconditioning hypoxia simulating ascent to 5000 in above sea level produced a long-lasting protective effect on synaptic activity.

引用

页码：1154 / 1156

页数：3

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