Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates

被引：16

作者：

Mittal, Vinita ^{[1
]}

Devitt, George ^{[2
]}

Nedeljkovic, Milos ^{[1
]}

Carpenter, Lewis G. ^{[1
]}

Chong, Harold M. H. ^{[3
]}

Wilkinson, James S. ^{[1
,2
]}

Mahajan, Sumeet ^{[2
,4
]}

Mashanovich, Goran Z. ^{[1
]}

机构：

[1] Univ Southampton, Optoelect Res Ctr, Southampton SO17 1BJ, Hants, England

[2] Univ Southampton, Inst Life Sci, Southampton SO17 1BJ, Hants, England

[3] Univ Southampton, Sch Elect & Comp Sci, Southampton SO17 1BJ, Hants, England

[4] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

来源：

BIOMEDICAL OPTICS EXPRESS | 2020年 / 11卷 / 08期

基金：

英国工程与自然科学研究理事会; 欧洲研究理事会;

关键词：

BOVINE SERUM-ALBUMIN; CONFORMATION; SILICON;

D O I：

10.1364/BOE.398013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer's and Parkinson's. It is important to study these conformational changes to identify and differentiate these diseases at an early stage so that timely medication is provided to patients. Mid-infrared spectroscopy can be used to monitor these changes by studying the line-shapes and the relative absorbances of amide bands present in proteins. This work focusses on the spectroscopy of the protein, Bovine Serum Albumin as an exemplar, and its aggregates using germanium on silicon waveguides in the 1900-1000 cm(-1) (5.3-10.0 mu m) spectral region. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License.

引用

页码：4714 / 4722

页数：9

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