Sesquiterpenes with various carbon skeletons from Ligularia virgaurea spp. oligocephala

被引：0
作者：
Wu, QX [1 ]
Wei, QY
Shi, YP
机构：
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Province, Lanzhou 730000, Peoples R China
[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
PHARMAZIE | 2006年 / 61卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new 8,9-seco-cacalol-type sesquiterpene lactones, ligulolide C (1 and 2) and six known sesquiterpenes, adenostylicle (3 and 4), cacalol (5), 1 -hydroxy-2-(3'-pentenyl)-3,7-dimethylbenzofuran (6), 1 beta, 6 alpha-dihydroxy-4(14)-eudesmene (7) and (+)-oplopanone (8), have been isolated from an extract of the whole plant of Ligularia virgaurea spp. oligocephala. The structures of 1 and 2 were confirmed by spectroscopic methods including 1D and 2D NMR spectra. A discussion of biogenesis of 1 and 2 was described. Cytotoxicity against selected cancer cells human promyelocytic leukemia (HL-60), human ovarian (HO-8910) and human lung epithehial (A-549) of compounds 1-8 were measured in vitro.
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页码：241 / 243
页数：3
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