Static Magnetic Field Induced Hypovitaminosis D in Rat

被引：6

作者：

Aida, Lahbib ^{[1
]}

Frederic, Lecomte ^{[2
]}

Soumaya, Ghodbane ^{[1
]}

Philippe, Hubert ^{[2
]}

Mohsen, Sakly ^{[1
]}

Hafedh, Abdelmelek ^{[1
]}

机构：

[1] Carthage Univ, Lab Integrat Physiol, Fac Sci Bizerte, Jarzouna, Tunisia

[2] Univ Liege, Inst Pharm, CIRM, Lab Analyt Chem,CHU, B-4000 Liege, Belgium

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2013年 / 75卷 / 09期

关键词：

25-hydroxyvitamin D-3; calcium; field; phosphorus; rat; static magnetic; BIOAVAILABLE VITAMIN-D; METABOLISM;

D O I：

10.1292/jvms.13-0105

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In the following study, we mainly investigate the effects of static magnetic field (SMF) (128 mT, 1 hr/day during 5 consecutive days) on 25-hydroxyvitamin D-3 and calcium homeostasis. Wistar male rats, weighing 50-70 g, were randomly divided into four experimental groups: control, SMF-exposed rat, co-exposed rats (the last day and after exposure rats received a single dose of vitamin D per os) and supplemented with vitamin D group (without exposure to SMF). Exposure to SMF induced a decrease of plasmatic 25-hydroxyvitamin D-3 level (P<0.001). While, calcium and phosphorus levels were not affected (P>0.05). The same treatment failed also to alter body, relative liver and kidney weights. Interestingly, oral supplementation with vitamin D corrected hypovitaminosis D induced by SMF. Likewise, the same treatment failed to alter calcium homeostasis. More studies are needed to evaluate how SMF induces hypovitaminosis D.

引用

页码：1181 / 1185

页数：5

共 20 条

[1] [Anonymous], BIOL EFFECTS ELECTRO
[2] Effect of 100 mT Homogeneous Static Magnetic Field on [Ca2+]c Response to ATP in HL-60 Cells Following GSH Depletion
Belton, Michelle
Prato, Frank S.
Rozanski, Camilla
Carson, Jeffrey J. L.
[J]. BIOELECTROMAGNETICS, 2009, 30 (04) : 322 - 329
[3] Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients
Bhan, Ishir
Powe, Camille E.
Berg, Anders H.
Ankers, Elizabeth
Wenger, Julia B.
Karumanchi, S. Ananth
Thadhani, Ravi I.
[J]. KIDNEY INTERNATIONAL, 2012, 82 (01) : 84 - 89
[4] FREE, AND NOT TOTAL, 1,25-DIHYDROXYVITAMIN-D REGULATES 25-HYDROXYVITAMIN-D METABOLISM BY KERATINOCYTES
BIKLE, DD
GEE, E
[J]. ENDOCRINOLOGY, 1989, 124 (02) : 649 - 654
[5] BRONNER F, 1973, ENG PRINCIPLES PHYSL, P227
[6] Bioavailable vitamin D in chronic kidney disease
Brown, Alex J.
Coyne, Daniel W.
[J]. KIDNEY INTERNATIONAL, 2012, 82 (01) : 5 - 7
[7] Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
Cheng, JB
Levine, MA
Bell, NH
Mangelsdorf, DJ
Russell, DW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (20) : 7711 - 7715
[8] Vitamin D-Binding Protein Directs Monocyte Responses to 25-Hydroxy- and 1,25-Dihydroxyvitamin D
Chun, Rene F.
Lauridsen, Anna L.
Suon, Lizabeth
Zella, Lee A.
Pike, J. Wesley
Modlin, Robert L.
Martineau, Adrian R.
Wilkinson, Robert J.
Adams, John
Hewison, Martin
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (07) : 3368 - 3376
[9] DeLuca HF, 2004, AM J CLIN NUTR, V80, p1689S, DOI 10.1093/ajcn/80.6.1689S
[10] Vitamin D
Dusso, AS
Brown, AJ
Slatopolsky, E
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 289 (01) : F8 - F28

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