Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts

被引：1

作者：

Bohle, D. Scott ^{[1
]}

Gu, Yuxuan ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 16期

基金：

加拿大自然科学与工程研究理事会;

关键词：

COMPLEXES; ARSENITE; BINDING; ACID; APL;

D O I：

10.1039/c3ob40268a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rapid thiolate exchange of dimethylarsonium, Me2As+, is observed between two different thiolate species in solution. NMR is used to characterize the equilibrium constants for interthiol transfer as well the rapid intra molecular conformational dynamics which leads to the coalescence of diastereotopic methyl resonances. These rapid exchange kinetics have important consequences of arsenic's toxicity and pharmacology.

引用

页码：2578 / 2581

页数：4