The center of the spinal cord may be central to its repair

被引:22
作者
Hawryluk, Gregory W. J. [1 ,2 ]
Fehlings, Michael G. [1 ,2 ,3 ]
机构
[1] Univ Toronto, Div Genet & Dev, Toronto Western Res Inst, Inst Med Sci, Toronto, ON M5T 2S8, Canada
[2] Univ Toronto, Div Neurosurg, Toronto, ON M5T 2S8, Canada
[3] Toronto Western Hosp, Univ Hlth Network, Spinal Program, Toronto, ON M5T 2S8, Canada
关键词
D O I
10.1016/j.stem.2008.08.009
中图分类号
Q813 [细胞工程];
学科分类号
摘要
A recent PLoS Biology report from Meletis et al. (2008) strongly suggests that ependymal cells are a key source of endogenous stem cells in the spinal cord. Advances in understanding endogenous neural stem cells may facilitate repair of the injured central nervous system.
引用
收藏
页码:230 / 232
页数:3
相关论文
共 10 条
[1]   INCORPORATION OF THYMIDINE-H3 BY CELLS IN NORMAL AND INJURED MOUSE SPINAL CORD [J].
ADRIAN, EK ;
WALKER, BE .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1962, 21 (04) :597-&
[2]   Emerging drugs for spinal cord injury [J].
Baptiste, Darryl C. ;
Fehlingst, Michael G. .
EXPERT OPINION ON EMERGING DRUGS, 2008, 13 (01) :63-80
[3]   Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells [J].
Cheng, Xiaoxin ;
Wang, Yaping ;
He, Qian ;
Qiu, Mengsheng ;
Whittemore, Scott R. ;
Cao, Qilin .
STEM CELLS, 2007, 25 (12) :3204-3214
[4]   Allodynia limits the usefulness of intraspinal neural stem cell grafts;: directed differentiation improves outcome [J].
Hofstetter, CP ;
Holmström, NAV ;
Lilja, JA ;
Schweinhardt, P ;
Hao, JX ;
Spenger, C ;
Wiesenfeld-Hallin, Z ;
Kurpad, SN ;
Frisén, J ;
Olson, L .
NATURE NEUROSCIENCE, 2005, 8 (03) :346-353
[5]   Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury [J].
Karimi-Abdolrezaee, S ;
Eftekharpour, E ;
Wang, J ;
Morshead, CM ;
Fehlings, MG .
JOURNAL OF NEUROSCIENCE, 2006, 26 (13) :3377-3389
[6]   Spinal cord injury reveals multilineage differentiation of ependymal cells [J].
Meletis, Konstantinos ;
Barnabe-Heider, Fanie ;
Carlen, Marie ;
Evergren, Emma ;
Tomilin, Nikolay ;
Shupliakov, Oleg ;
Frisen, Jonas .
PLOS BIOLOGY, 2008, 6 (07) :1494-1507
[7]   Cell proliferation and nestin expression in the ependyma of the adult rat spinal cord after injury [J].
Namiki, J ;
Tator, CH .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1999, 58 (05) :489-498
[8]   Multifaceted dialogue between graft and host in neurotransplantation [J].
Ourednik, V ;
Ourednik, J .
JOURNAL OF NEUROSCIENCE RESEARCH, 2004, 76 (02) :193-204
[9]   Spinal cord injury: Time to move? [J].
Rossignol, Serge ;
Schwab, Martin ;
Schwartz, Michal ;
Fehlings, Michael G. .
JOURNAL OF NEUROSCIENCE, 2007, 27 (44) :11782-11792
[10]  
Shetty AK, 2000, J NEUROSCI, V20, P8788