Update on small intestinal stem cells

被引：7

作者：

Tesori, Valentina ^{[1
,2
]}

Puglisi, Maria Ausiliatrice ^{[2
]}

Lattanzi, Wanda ^{[3
]}

Gasbarrini, Giovanni Battista ^{[4
]}

Gasbarrini, Antonio ^{[2
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dept Internal Med & Gastroenterol, I-00197 Rome, Italy

[2] Gemelli Hosp, Dept Internal Med, I-00168 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Inst Anat & Cell Biol, I-00168 Rome, Italy

[4] Med Res Fdn ONLUS, I-40123 Bologna, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2013年 / 19卷 / 29期

关键词：

Intestinal stem cells; Organoids; Intestinal regeneration; Lgr5; Niche; MICROVILLUS INCLUSION DISEASE; SELF-RENEWAL; HEMATOPOIETIC STEM; STROMAL CELLS; IN-VITRO; EPITHELIAL DEVELOPMENT; SIGNALING PATHWAY; PANETH CELLS; BONE-MARROW; PROTEIN;

D O I：

10.3748/wjg.v19.i29.4671

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Among somatic stem cells, those residing in the intestine represent a fascinating and poorly explored research field. Particularly, somatic stem cells reside in the small intestine at the level of the crypt base, in a constant balance between self-renewal and differentiation. Aim of the present review is to delve into the mechanisms that regulate the delicate equilibrium through which intestinal stem cells orchestrate intestinal architecture. To this aim, special focus will be addressed to identify the integrating signals from the surrounding niche, supporting a model whereby distinct cell populations facilitate homeostatic vs injury-induced regeneration. (C) 2013 Baishideng. All rights reserved.

引用

页码：4671 / 4678

页数：8

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