A History of the Development of Brucella Vaccines

被引：118
作者：
Daniel Avila-Calderon, Eric [1 ]
Lopez-Merino, Ahide [1 ]
Sriranganathan, Nammalwar [2 ]
Boyle, StephenM. [2 ]
Contreras-Rodriguez, Araceli [1 ]
机构：
[1] Inst Politecn Nacl, Dept Microbiol, Escuela Nacl Ciencias Biol, Mexico City 11340, DF, Mexico
[2] Virginia Tech, Ctr Mol Med & Infect Dis, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24060 USA
来源：
BIOMED RESEARCH INTERNATIONAL | 2013年 / 2013卷
关键词：
OUTER-MEMBRANE VESICLES; ZN SUPEROXIDE-DISMUTASE; DNA VACCINE; PROTECTIVE IMMUNITY; BALB/C MICE; PERIPLASMIC PROTEINS; INSOLUBLE FRACTION; CONFERS PROTECTION; SUBUNIT VACCINE; OVIS INFECTION;
D O I：
10.1155/2013/743509
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Brucellosis is a worldwide zoonosis affecting animal and human health. In the last several decades, much research has been performed to develop safer Brucella vaccines to control the disease mainly in animals. Till now, no effective human vaccine is available. The aim of this paper is to review and discuss the importance of methodologies used to develop Brucella vaccines in pursuing this challenge.
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页数：8
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