Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium

被引：58

作者：

Campa, Daniele ^{[1
]}

Rizzato, Cosmeri ^{[1
]}

Capurso, Gabriele ^{[2
]}

Giese, Nathalia ^{[3
]}

Funel, Niccola ^{[4
]}

Greenhalf, William ^{[5
,6
]}

Soucek, Pavel ^{[7
]}

Gazouli, Maria ^{[8
]}

Pezzilli, Raffaele ^{[9
]}

Pasquali, Claudio ^{[10
]}

Talar-Wojnarowska, Renata ^{[11
]}

Cantore, Maurizio ^{[12
]}

Andriulli, Angelo ^{[13
,14
]}

Scarpa, Aldo ^{[15
]}

Jamroziak, Krzysztof ^{[16
]}

Delle Fave, Gianfranco ^{[2
]}

Costello, Eithne ^{[5
,6
]}

Khaw, Kay-Tee ^{[17
]}

Heller, Anette ^{[3
]}

Key, Tim J. ^{[24
]}

Theodoropoulos, George ^{[8
]}

Malecka-Panas, Ewa ^{[11
]}

Mambrini, Andrea ^{[12
]}

Bambi, Franco ^{[18
]}

Landi, Stefano ^{[19
]}

Pedrazzoli, Sergio ^{[10
]}

Bassi, Claudio ^{[20
]}

Pacetti, Paola ^{[12
]}

Piepoli, Ada ^{[13
,14
]}

Tavano, Francesca ^{[13
,14
]}

di Sebastiano, Pierluigi ^{[13
,14
]}

Vodickova, Ludmila ^{[21
,22
]}

Basso, Daniela ^{[23
]}

Plebani, Mario ^{[23
]}

Fogar, Paola ^{[23
]}

Buechler, Markus W. ^{[3
]}

Bugert, Peter ^{[25
]}

Vodicka, Pavel ^{[21
,22
]}

Boggi, Ugo ^{[4
]}

Neoptolemos, John P. ^{[5
,6
]}

Werner, Jens ^{[3
]}

Canzian, Federico ^{[1
]}

机构：

[1] German Canc Res Ctr, D-69120 Heidelberg, Germany

[2] Univ Roma La Sapienza, Digest & Liver Dis Unit, Rome, Italy

[3] Heidelberg Univ, Clin Gen Visceral & Transplantat Surg, Heidelberg, Germany

[4] Univ Hosp Pisa, Dept Surg, Unit Expt Surg Pathol, Pisa, Italy

[5] Natl Inst Hlth Res, Pancreas Biomed Res Unit, Liverpool, Merseyside, England

[6] Natl Inst Hlth Res, Liverpool Expt Canc Med Ctr, Liverpool, Merseyside, England

[7] Natl Inst Publ Hlth, Dept Toxicogen, Prague, Czech Republic

[8] Univ Athens, Sch Med, Biol Lab, GR-11527 Athens, Greece

[9] St Orsola Malpighi Hosp, Dept Digest Dis & Internal Med, Pancreas Unit, Bologna, Italy

[10] Univ Padua, Clin Chirurg 4, Dept Surg Oncol & Gastroenterol, I-35100 Padua, Italy

[11] Med Univ Lodz, Dept Digest Tract Dis, Lodz, Poland

[12] ASL1 Massa Carrara, Dept Oncol, Massa Carrara, Italy

[13] Sci Inst & Reg Gen Hosp Casa Sollievo Sofferenza, Opera Padre Pio Pietrelcina San Giovanni Rotondo, Dept Gastroenterol, Foggia, Italy

[14] Sci Inst & Reg Gen Hosp Casa Sollievo Sofferenza, Opera Padre Pio Pietrelcina San Giovanni Rotondo, Dept Surg, Foggia, Italy

[15] Univ & Hosp Trust Verona, ARC NET Ctr Appl Res Canc, Verona, Italy

[16] Med Univ Lodz, Dept Hematol, Lodz, Poland

[17] Univ Cambridge, Sch Clin Med, Cambridge, England

[18] Osped Pediat, AOU Meyer, Florence, Italy

[19] Univ Pisa, Dept Biol, Pisa, Italy

[20] Univ & Hosp Trust Verona, Dept Surg & Oncol, Verona, Italy

[21] Acad Sci Czech Republ, Inst Expt Med, Dept Mol Biol Canc, Prague, Czech Republic

[22] Charles Univ Prague, Fac Med 1, Prague, Czech Republic

[23] Univ Hosp Padova, Dept Lab Med, Padua, Italy

[24] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[25] Heidelberg Univ, German Red Cross Blood Serv Baden Wurttemberg Hes, Inst Transfus Med & Immunol, Med Fac Mannheim, Mannheim, Germany

来源：

DIGESTIVE AND LIVER DISEASE | 2013年 / 45卷 / 02期

基金：

英国医学研究理事会;

关键词：

Cancer susceptibility; Genetic polymorphisms; Genetic susceptibility; Pancreatic cancer; GENOME-WIDE ASSOCIATION; DNA COPY NUMBER; RISK-FACTORS; COHORT; VARIANTS; PALB2; LOCI;

D O I：

10.1016/j.dld.2012.09.014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic cancer is the fourth leading cause of cancer deaths in the European Union and in the USA, but little is known about its genetic susceptibility. The PANcreatic Disease ReseArch (PANDoRA) consortium was established to unite the efforts of different research groups; its aim is to create a large bio-database to uncover new genetic factors for pancreatic cancer risk, response to treatment, and patient survival. So far 2220 cases of pancreatic adenocarcinoma, a smaller number of cases of endocrine pancreatic tumours (n = 86), chronic pancreatitis (n = 272) and 3847 healthy controls have been collected. As a collective effort of the consortium, SNPs associated with pancreatic adenocarcinoma risk from a genome-wide association study performed in Caucasians were replicated. The possibility that the same genetic polymorphisms may influence patient survival as well was also addressed. This collective effort is particularly important for pancreatic cancer because it is a relatively rare disease for which little is known about aetiopathogenesis and risk factors. The recruitment of additional collaborators and partner institutions is continuously on-going. (C) 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：95 / 99

页数：5

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