Kostchyienones A and B, new antiplasmodial and cytotoxicity of limonoids from the roots of Pseudocedrela kotschyi (Schweinf.) Harms

被引：13

作者：

Sidjui, Lazare S. ^{[1
,2
,3
]}

Nganso, Yves O. D. ^{[4
]}

Toghueo, Rufin M. K. ^{[5
]}

Wakeu, Brussine N. K. ^{[2
]}

Dameue, Joel T. ^{[2
]}

Mkounga, Pierre ^{[2
]}

Adhikari, Achyut ^{[6
]}

Lateef, Mehreen ^{[7
]}

Folefoc, Gabriel N. ^{[2
]}

Ali, Muhammad S. ^{[3
]}

机构：

[1] Inst Med Res & Med Plant Studies, POB 13033, Yaounde, Cameroon

[2] Univ Yaound I, TWAS Res Unit, Fac Sci, Dept Organ Chem, POB 812, Yaounde, Cameroon

[3] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[4] Univ Maroua, Fac Sci, Dept Chem, POB 814, Maroua, Cameroon

[5] Univ Yaounde I, Fac Sci, Antimicrobial & Biocontrol Agent Unit, Lab Phytobiochem & Med Plant Study, POB 812, Yaounde, Cameroon

[6] Tribhuvan Univ, Cent Dept Chem, Kathmandu, Nepal

[7] Pakistan Council Sci & Ind Res Labs Complex, Pharmaceut Res Ctr, Karachi 75280, Pakistan

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2018年 / 73卷 / 3-4期

关键词：

antiplasmodial activity; kostchyienones A; kostchyienone B; limonoids; Pseudocedrela kostchyi; ANTIMALARIAL ACTIVITY; MEDICINAL-PLANTS; PSEUDRELONE-B; GROWTH;

D O I：

10.1515/znc-2017-0102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new limonoids, kostchyienones A (1) and B (2), along with 12 known compounds 3-14 were isolated from the roots of Pseudocedrela kostchyi. Compound (7) was isolated for the first time from a natural source. Their structures were elucidated on the basis of spectroscopic evidence. Compounds 1-6 and 13-14 gave IC50 values ranging from 0.75 to 5.62 mu g/mL for antiplasmodial activity against chloroquine-sensitive (Pf3D7) and chloroquine-resistant (PfINDO) strains of Plasmodium falciparum. Compound 5 showed moderate potential cytotoxicity against the HEK239T cell line with an IC50 value of 22.2 +/- 0.89 mu g/mL. The antiplasmodial efficacy of the isolated compounds supports the medicinal value of this plant and its potential to provide novel antimalarial drugs.

引用

页码：153 / 160

页数：8

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