Kostchyienones A and B, new antiplasmodial and cytotoxicity of limonoids from the roots of Pseudocedrela kotschyi (Schweinf.) Harms

被引：13

作者：

Sidjui, Lazare S. ^{[1
,2
,3
]}

Nganso, Yves O. D. ^{[4
]}

Toghueo, Rufin M. K. ^{[5
]}

Wakeu, Brussine N. K. ^{[2
]}

Dameue, Joel T. ^{[2
]}

Mkounga, Pierre ^{[2
]}

Adhikari, Achyut ^{[6
]}

Lateef, Mehreen ^{[7
]}

Folefoc, Gabriel N. ^{[2
]}

Ali, Muhammad S. ^{[3
]}

机构：

[1] Inst Med Res & Med Plant Studies, POB 13033, Yaounde, Cameroon

[2] Univ Yaound I, TWAS Res Unit, Fac Sci, Dept Organ Chem, POB 812, Yaounde, Cameroon

[3] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[4] Univ Maroua, Fac Sci, Dept Chem, POB 814, Maroua, Cameroon

[5] Univ Yaounde I, Fac Sci, Antimicrobial & Biocontrol Agent Unit, Lab Phytobiochem & Med Plant Study, POB 812, Yaounde, Cameroon

[6] Tribhuvan Univ, Cent Dept Chem, Kathmandu, Nepal

[7] Pakistan Council Sci & Ind Res Labs Complex, Pharmaceut Res Ctr, Karachi 75280, Pakistan

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2018年 / 73卷 / 3-4期

关键词：

antiplasmodial activity; kostchyienones A; kostchyienone B; limonoids; Pseudocedrela kostchyi; ANTIMALARIAL ACTIVITY; MEDICINAL-PLANTS; PSEUDRELONE-B; GROWTH;

D O I：

10.1515/znc-2017-0102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new limonoids, kostchyienones A (1) and B (2), along with 12 known compounds 3-14 were isolated from the roots of Pseudocedrela kostchyi. Compound (7) was isolated for the first time from a natural source. Their structures were elucidated on the basis of spectroscopic evidence. Compounds 1-6 and 13-14 gave IC50 values ranging from 0.75 to 5.62 mu g/mL for antiplasmodial activity against chloroquine-sensitive (Pf3D7) and chloroquine-resistant (PfINDO) strains of Plasmodium falciparum. Compound 5 showed moderate potential cytotoxicity against the HEK239T cell line with an IC50 value of 22.2 +/- 0.89 mu g/mL. The antiplasmodial efficacy of the isolated compounds supports the medicinal value of this plant and its potential to provide novel antimalarial drugs.

引用

页码：153 / 160

页数：8

共 28 条

[1]

[Anonymous], MED CHEM

[2] Indigenous knowledge system for treatment of trypanosomiasis in Kaduna state of Nigeria [J].

Atawodi, SE ;

Ameh, DA ;

Ibrahim, S ;

Andrew, JN ;

Nzelibe, HC ;

Onyike, EO ;

Anigo, KM ;

Abu, EA ;

James, DB ;

Njoku, GC ;

Sallau, AB .

JOURNAL OF ETHNOPHARMACOLOGY, 2002, 79 (02) :279-282

[3] In vitro antimalarial activity of limonoids from Khaya grandifoliola CDC (Meliaceae) [J].

Bickii, J ;

Njifutie, N ;

Foyere, JA ;

Basco, LK ;

Ringwald, P .

JOURNAL OF ETHNOPHARMACOLOGY, 2000, 69 (01) :27-33

[4]

Chin P.W., 2011, CHEM PHARM BULL, V59, P407

[5] Antimalarial potential of the ethanolic leaf extract of Pseudocedrala kotschyi [J].

Christian, Akuodor Godwin ;

Ahunna, Ajoku Gloria ;

Nwakaego, Ezeunala Mercy ;

Chimsorom, Chilaka Kingsley ;

Chile, Asika Ebere .

JOURNAL OF ACUTE DISEASE, 2015, 4 (01) :23-27

[6] Antiplasmodial Efficacy of Stem Bark Extracts of Pseudocedrela kotschyi in Mice Infected with Plasmodium berghei berghei [J].

Dawet, A. ;

Yakubu, D. P. .

BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH, 2014, 4 (05) :594-607

[7] Antiplasmodial constituents of Cajanus cajan [J].

Duker-Eshun, G ;

Jaroszewski, JW ;

Asomaning, WA ;

Oppong-Boachie, F ;

Christensen, SB .

PHYTOTHERAPY RESEARCH, 2004, 18 (02) :128-130

[8]

EKONG DEU, 1967, TETRAHEDRON LETT, P3525, DOI 10.1016/S0040-4039(01)89835-X

[9] Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell. [J].

El Tahir, A ;

Satti, GMH ;

Khalid, SA .

JOURNAL OF ETHNOPHARMACOLOGY, 1999, 64 (03) :227-233

[10]

Georgewill U. O., 2009, Eastern Journal of Medicine, V14, P17

← 1 2 3 →