Gamma Interferon Release Assay for Monitoring of Treatment Response for Active Tuberculosis: an Explosion in the Spaghetti Factory

被引：47

作者：

Denkinger, Claudia M. ^{[1
,2
]}

Pai, Madhukar ^{[2
,3
]}

Patel, Meena ^{[3
]}

Menzies, Dick ^{[2
,3
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

[2] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada

[3] Montreal Chest Inst, Resp Epidemiol & Clin Res Unit, Montreal, PQ, Canada

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2013年 / 51卷 / 02期

关键词：

WITHIN-SUBJECT VARIABILITY; IFN-GAMMA; T-CELLS; REPRODUCIBILITY; ANTIGENS;

D O I：

10.1128/JCM.02278-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Few studies have correlated the results of interferon (gamma interferon) release assays (IGRAs) with known markers of tuberculosis (TB) treatment response. We report the results of serial QuantiFERON-TB gold in-tube assay (QFT) testing on 149 patients with active tuberculosis and correlate the results with smear and culture conversion. We show that QFT results do not offer much value for treatment monitoring of TB disease.

引用

页码：607 / 610

页数：4

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