Morphofunctional Reaction of Bacteria Treated with Antimicrobial Peptides Derived from Farm Animal Platelets

被引:2
|
作者
Vasilchenko, Alexey S. [1 ,2 ]
Dymova, Veronica V. [3 ]
Kartashova, Olga L. [2 ]
Sycheva, Maria V. [2 ,3 ]
机构
[1] Orenburg State Univ, Orenburg 460018, Russia
[2] RAS, Inst Cellular & Intracellular Symbiosis, Orenburg 460000, Russia
[3] Orenburg State Agrarian Univ, Orenburg 460795, Russia
基金
俄罗斯基础研究基金会;
关键词
Antimicrobial peptides; Antibiotics; Atomic force microscopy; Platelet microbicidal proteins; Farm animals; ATOMIC-FORCE MICROSCOPY; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; RESISTANCE; MECHANISMS; AGENTS;
D O I
10.1007/s12602-014-9172-4
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Classical microbiological approach and atomic force microscopy were used to evaluate the mechanisms of biological activity of antimicrobial peptides (AMPs) derived from platelets of farm animals. It is established that AMPs inhibit both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) microorganisms. Differences revealed in the biological activity of AMP preparations obtained from the organisms of various species can be reduced to quantitative differences. While qualitative changes of bacterial cells were substantially similar, changes in the integrity of cell walls resulted in disintegration of the bacterial outer and/or cytoplasmic membranes.
引用
收藏
页码:60 / 65
页数:6
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