A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

被引：73

作者：

Chen, Jie ^{[1
]}

Zhou, Ling ^{[1
]}

Yeung, Ying-Yeung ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 19期

关键词：

RING-CLOSING METATHESIS; ASYMMETRIC BROMOLACTONIZATION; EFFICIENT SYNTHESIS; HECK REACTION; PYRROLIDINE; ACID; POTENT; BROMOCYCLIZATION; HYDROAMINATION; HOMOAZASUGARS;

D O I：

10.1039/c2ob25327e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and highly enantioselective approach towards 2-substituted 3-bromopyrrolidines has been developed. The process involves an amino-thiocarbamate catalyzed bromoaminocyclization of 1,2-disubstituted olefinic amides. The pyrrolidine products could readily be converted into other useful building blocks including a dihydropyrrole and a 2-substituted pyrrolidine.

引用

页码：3808 / 3811

页数：4

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