New Targets for Acetylation in Autophagy

被引：32

作者：

Hamai, Ahmed ^{[1
]}

Codogno, Patrice ^{[1
]}

机构：

[1] Univ Paris 11, INSERM, U984, F-92296 Chatenay Malabry, France

来源：

SCIENCE SIGNALING | 2012年 / 5卷 / 231期

关键词：

MAMMALIAN AUTOPHAGY; SPERMIDINE; PATHWAY; ATG3;

D O I：

10.1126/scisignal.2003187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macroautophagy is an evolutionarily conserved homeostatic process that mediates the degradation of long-lived cytoplasmic components in eukaryotes, which allows cells to survive stresses such as inflammation, hypoxia, and deprivation of nutrients or growth factors. At least 30 members of the Atg (autophagy-related) protein family orchestrate this degradative process. Additional complexity resides in the signaling networks controlling the autophagic process, which include various posttranslational modifications of key components. Evidence is accumulating that protein acetylation represents an evolutionarily conserved mechanism tightly regulating macroautophagy.

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