Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches-An Overview

被引：41

作者：

Carballo-Pedrares, Natalia ^{[1
]}

Fuentes-Boquete, Isaac ^{[1
,2
]}

Diaz-Prado, Silvia ^{[1
,2
]}

Rey-Rico, Ana ^{[1
]}

机构：

[1] Univ A Coruna, Ctr Invest Cient Avanzadas CICA, Cell Therapy & Regenerat Med Unit, La Coruna 15071, Spain

[2] Univ Coruna UDC, Dept Fisioterapia Med & Ciencias Biomed, Fac Ciencias Salud,Serv Galego Saude SERGAS, Inst Invest Biomed A Coruna INIBIC,Complexo Hosp, La Coruna 15071, Galicia, Spain

来源：

PHARMACEUTICS | 2020年 / 12卷 / 08期

关键词：

musculoskeletal tissue; cardiovascular tissue; wound healing; nervous tissue; gene therapy; controlled delivery; hydrogels; nonviral vectors; HYALURONIC-ACID HYDROGELS; STEM-CELLS; SUSTAINED DELIVERY; GROWTH-FACTORS; DNA DELIVERY; IN-VITRO; THERAPY; DESIGN; SYSTEM; TRANSFECTION;

D O I：

10.3390/pharmaceutics12080752

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can provide a spatially and temporarily defined supply of specific gene sequences into the target tissue cells that are overexpressing or silencing the original gene, which can promote natural repairing mechanisms to achieve the desired effect. In the present work, we provide an overview of the most avant-garde approaches using various hydrogels systems for controlled delivery of therapeutic nucleic acid molecules in different regenerative medicine approaches.

引用

页码：1 / 21

页数：21

共 125 条

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