Efficient inhibition of human papillomavirus 16 L1 pentamer formation by a carboxylatopillarene and a p-sulfonatocalixarene

被引：81

作者：

Zheng, Dong-Dong ^{[1
]}

Fu, Ding-Yi ^{[1
]}

Wu, Yuqing ^{[1
]}

Sun, Yu-Long ^{[1
]}

Tan, Li-Li ^{[1
]}

Zhou, Ting ^{[1
]}

Ma, Shi-Qi ^{[2
]}

Zha, Xiao ^{[2
]}

Yang, Ying-Wei ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China

[2] Sichuan Tumor Hosp & Inst, Chengdu 610041, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 24期

基金：

中国国家自然科学基金;

关键词：

VIRUS-LIKE PARTICLES; CERVICAL-CANCER; IN-VITRO; WATER; RECOGNITION; RELEASE; NANOPARTICLES; COMPLEXATION; INFECTION; RECEPTOR;

D O I：

10.1039/c3cc49789e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pillarenes and calixarenes showed obvious inhibition of HPV16 L1 pentamer formation via their selective binding to Arg and Lys residues at the monomer interface, which was reversible after the release of cyclic arenes. Pillarenes are more effective than calixarenes in terms of the inhibition efficiency, attributing to the different kinetics and binding affinity.

引用

页码：3201 / 3203

页数：3

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