Synthesis and anticancer activity of some fused pyrimidines and related heterocycles

被引：50
作者：
Al-Issa, S. A. [1 ]
机构：
[1] AbdulRahman Univ, Fac Sci, Dept Chem, Riyadh, Saudi Arabia
来源：
SAUDI PHARMACEUTICAL JOURNAL | 2013年 / 21卷 / 03期
关键词：
Pyrimido[3,2-b]1,2,4,5-tetrazine; Pyrimido[3,2-b]1,2,4-triazine; Pyrimido[3,2-b]-1,2,4-triazole; Pyrimidine derivatives; Anticancer; DERIVATIVES; INHIBITORS; ANTITUMOR; ANALOGS;
D O I：
10.1016/j.jsps.2012.09.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
On account of the reported anticancer of pyrimidine and condensed pyrimidine, a new pyrimido [3,2-b]-1,2,4,5-tetrazine 3(a,b), 5(c,d), 6, 9, pyrimido [3,2-b]-1,2,4-triazine 10, 11, pyrimido [3,2-b]-1,2,4-triazole 12 and pyrimidine derivatives 1,2(a,b), 4(c,d), 8, 13, 14, 15 and 16 were synthesized through different chemical reactions. Structures of all synthesized compounds were supported by spectral and elemental analyses. The obtained compounds were evaluated for their in vitro antitumor activity against human liver cancer cell line (HEPG2). (C) 2012 King Saud University. Production and hosting by Elsevier B. V. All rights reserved.
引用
收藏
页码：305 / 316
页数：12
相关论文
共 50 条
  • [21] Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety
    Amr, Abdel-Galil El-Sayed
    Abdel-Hafez, Naglaa Abdel-Samei
    Mohamed, Salwa Fahem
    Abdalla, Mohamed Mostafa
    TURKISH JOURNAL OF CHEMISTRY, 2009, 33 (03) : 421 - 432
  • [22] Efficient synthesis of thieno[2,3-d]pyrimidines and related fused systems
    Aly, Aly A.
    Behalo, Mohamed S.
    JOURNAL OF CHEMICAL RESEARCH, 2010, (10) : 571 - 575
  • [23] Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
    Aksenov, Nicolai A.
    Aksenov, Alexander, V
    Kirilov, Nikita K.
    Arutiunov, Nikolai A.
    Aksenov, Dmitrii A.
    Maslivetc, Vladimir
    Zhao, Zhenze
    Du, Liqin
    Rubin, Michael
    Kornienko, Alexander
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, 18 (34) : 6651 - 6664
  • [24] Synthesis, Characterization, and Anticancer Activity (MCF-7) of Some Acetanilide-based Heterocycles
    Abdel-Latif, Ehab
    Keshk, Eman M.
    Khalil, Abdel-Galil M.
    Saeed, Ali
    Metwally, Heba M.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (10) : 2334 - 2341
  • [25] Synthesis of Novel Thiazolyl-Pyrimidines and Their Anticancer Activity in Vitro
    Shi, Hai-Bo
    Li, Hai-Bo
    Lu, Kong-Qin
    Zhu, Xia-Re
    Hu, Wei-Xiao
    Pei, Wen
    ARCHIV DER PHARMAZIE, 2011, 344 (10) : 675 - 683
  • [26] Nitrogen-containing Fused Heterocycles: Organic Synthesis and Applications as Potential Anticancer Agents
    Ledade, Pankaj V.
    Lambat, Trimurti L.
    Gunjate, Jitendra K.
    Chopra, Paavan K. P. G.
    Bhute, Amitkumar V.
    Lanjewar, Mamata R.
    Kadu, Pooja M.
    Dongre, Utpal J.
    Mahmood, Sami H.
    CURRENT ORGANIC CHEMISTRY, 2023, 27 (03) : 206 - 222
  • [27] Synthesis of Fused Pyridine Carboxylates by Reaction of β-Alkoxyvinyl Glyoxylates with Amino Heterocycles
    Stepaniuk, Oleksandr O.
    Rudenko, Tymofii, V
    Vashchenko, Bohdan V.
    Matvienko, Vitalii O.
    Kondratov, Ivan S.
    Tolmachev, Andrey A.
    Grygorenko, Oleksandr O.
    SYNTHESIS-STUTTGART, 2020, 52 (13): : 1915 - 1926
  • [28] Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines
    Bunev, Alexander S.
    Khochenkov, Dmitry A.
    Khochenkova, Yulia A.
    Machkova, Yulia S.
    Varakina, Elena V.
    Gasanov, Rovshan E.
    Troshina, Marina A.
    Avdyakova, Olga S.
    SYNTHETIC COMMUNICATIONS, 2021, 51 (16) : 2521 - 2527
  • [29] Current scenario of fused pyrimidines with in vivo anticancer therapeutic potential
    Xu, Zhi
    Wang, Li
    Hu, Hongyan
    ARCHIV DER PHARMAZIE, 2024, 357 (08)
  • [30] Synthesis of various pyrimidines and fused pyrimidines derivatives by telescopic reactions
    Katiya, Manish M.
    Dhonde, Madhukar G.
    Ganorkar, Kapil S.
    Gajbhiye, Jayant M.
    RESULTS IN CHEMISTRY, 2025, 15
12345