Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Amidoximes and Aldehydes in the Superbasic System NaOH/DMSO

被引：6

作者：

Shetnev, A. A. ^{[1
]}

Pankratieva, V. E. ^{[2
]}

Kunichkina, A. S. ^{[2
]}

Vlasov, A. S. ^{[1
]}

Proskurina, I. K. ^{[2
]}

Kotov, A. D. ^{[2
]}

Korsakov, M. K. ^{[1
]}

机构：

[1] Ushinsky Yaroslavl State Pedag Univ, Dorogov Pharmaceut Technol Transfer Ctr, Yaroslavl 150000, Russia

[2] Ushinsky Yaroslavl State Pedag Univ, Yaroslavl 150000, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 07期

基金：

俄罗斯基础研究基金会;

关键词：

aldehyde; amidoxime; oxadiazole; superbasic medium; condensation; dimethyl sulfoxide; sodium hydroxide; ONE-POT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; NITRILE OXIDE; DERIVATIVES; EFFICIENT; ACIDS; CYCLIZATION; INHIBITORS; PERIPHERY; FACILE;

D O I：

10.1134/S107042802007009X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new procedure has been proposed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles by reaction of amidoximes with aldehydes in the superbasic system NaOH/DMSO at room temperature. The scope of the proposed procedure has been demonstrated by 15 syntheses from various amidoximes and aromatic aldehydes with 27-76% yields. The procedure is inapplicable to aliphatic aldehydes.

引用

页码：1181 / 1186

页数：6

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