Metal ion transporters and homeostasis

被引：257
作者：
Nelson, N [1 ]
机构：
[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem, IL-69978 Tel Aviv, Israel
来源：
EMBO JOURNAL | 1999年 / 18卷 / 16期
关键词：
copper; human diseases; iron; manganese; metal ions; transport; yeast;
D O I：
10.1093/emboj/18.16.4361
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transition metals are essential for many metabolic processes and their homeostasis is crucial for life. Aberrations in the cellular metal ion concentrations may lead to cell death and severe diseases. Metal ion transporters play a major role in maintaining the correct concentrations of the various metal ions in the different cellular compartments. Recent studies of yeast mutants revealed key elements in metal ion homeostasis, including novel transport systems. Several of the proteins discovered in yeast are highly conserved, and defects in some of the yeast mutants could be complemented by their human homologs. The studies of yeast metal ion transporters helped to unravel the molecular mechanism of macrophage defense against bacterial infection and hereditary diseases.
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收藏
页码：4361 / 4371
页数：11
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