Two neolignans from Perilla frutescens and their inhibition of nitric oxide synthase and tumor necrosis factor-α expression in murine macrophage cell line RAW 264.7

被引：32

作者：

Ryu, JH ^{[1
]}

Son, HJ

Lee, SH

Sohn, DH

机构：

[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

[2] Wonkwang Univ, Coll Pharm, Geonbuk 570749, South Korea

[3] Wonkwang Univ, Med Resources Res Ctr, Iksan 570749, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)00812-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two neolignans were isolated from leaves of Perilla fratescens (Labiatae) as inhibitors of nitric oxide syntheses (IC50 5.9 muM and 53.5 muM, respectively) and tumor necrosis factor-alpha in lipopolysaccharide-activated RAW 264.7 cells. Their structures were identified as 1p,2alpha,3beta,4alpha-1,2-dimethyl-3,4-bis-(2,4,5-trimethoxyphenyl)-cyclobutane (magnosalin), and 1alpha,2beta,3beta,4beta-1,2-dimethyl-3,4-bis-(2,4,5-trimethoxyphenyl)-cyclobutane (andamanicin), and their activities were confirmed as resulted from the suppressed expression of inducible nitric oxide synthase enzyme and from the secretion of tumor necrosis factor-alpha from activated macropha. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：649 / 651

页数：3

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