Neurotoxic effects of berberine on long-term l-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson's disease
被引:44
作者:
Shin, Keon Sung
论文数: 0引用数: 0
h-index: 0
机构:
Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Chungbuk Natl Univ, Res Ctr Bioresource & Hlth, Cheongju 361763, South KoreaChungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Shin, Keon Sung
[1
,2
]
Choi, Hyun Sook
论文数: 0引用数: 0
h-index: 0
机构:
Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Chungbuk Natl Univ, Res Ctr Bioresource & Hlth, Cheongju 361763, South KoreaChungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Choi, Hyun Sook
[1
,2
]
Zhao, Ting Ting
论文数: 0引用数: 0
h-index: 0
机构:
Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Chungbuk Natl Univ, Res Ctr Bioresource & Hlth, Cheongju 361763, South KoreaChungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Zhao, Ting Ting
[1
,2
]
Suh, Kwang Hoon
论文数: 0引用数: 0
h-index: 0
机构:
Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Chungbuk Natl Univ, Res Ctr Bioresource & Hlth, Cheongju 361763, South KoreaChungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Suh, Kwang Hoon
[1
,2
]
Kwon, Ik Hyun
论文数: 0引用数: 0
h-index: 0
机构:
Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Chungbuk Natl Univ, Res Ctr Bioresource & Hlth, Cheongju 361763, South KoreaChungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Kwon, Ik Hyun
[1
,2
]
Choi, Soon Ok
论文数: 0引用数: 0
h-index: 0
机构:
Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Chungbuk Natl Univ, Res Ctr Bioresource & Hlth, Cheongju 361763, South KoreaChungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Choi, Soon Ok
[1
,2
]
Lee, Myung Koo
论文数: 0引用数: 0
h-index: 0
机构:
Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Chungbuk Natl Univ, Res Ctr Bioresource & Hlth, Cheongju 361763, South KoreaChungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
Lee, Myung Koo
[1
,2
]
机构:
[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
[2] Chungbuk Natl Univ, Res Ctr Bioresource & Hlth, Cheongju 361763, South Korea
The effects of berberine on long-term administration of l-DOPA in 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease (PD) were investigated. Rat models of PD were prepared by 6-OHDA lesions in the ipsilateral sides, and then were treated with berberine (5 and 15 mg/kg) and/or l-DOPA (10 mg/kg) once daily for 21 days. Treatments with either concentration of berberine (5 and 15 mg/kg) in 6-OHDA-lesioned groups decreased the numbers of tyrosine hydroxylase (TH)-immunopositive neurons in the substantia nigra and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum as compared to 6-OHDA-lesioned groups. In addition, dopaminergic neuronal cell death of the ipsilateral sides in 6-OHDA-lesioned groups was attenuated by l-DOPA administration. However, both concentrations of berberine in 6-OHDA-lesioned groups treated with l-DOPA aggravated the numbers of TH-immunopositive neurons in the substantia nigra and the levels of dopamine, norepinephrine, DOPAC and HVA in the striatum as compared to rats not treated with berberine. These results suggest that berberine leads to the degeneration of dopaminergic neuronal cells in the substantia nigra in the rat model of PD with chronic l-DOPA administration. Long-term l-DOPA therapy that may involve possibly neurotoxic isoquinoline agents including berberine should involve monitoring for adverse symptoms.