Potential missing steps for a wide use of dried matrix spots in biomedical analysis

被引：13

作者：

Deglon, Julien ^{[1
]}

Leuthold, Luc Alexis ^{[2
]}

Thomas, Aurelien ^{[3
]}

机构：

[1] Univ Hosp Geneva, Univ Ctr Legal Med, Toxicol Unit, CURML, CH-1211 Geneva, Switzerland

[2] Novartis Inst Biomed Res, DMPK, Adv Bioanalyt & Automat, Basel, Switzerland

[3] Univ Lausanne, Toxicol Unit, CURML, Lausanne, Switzerland

来源：

BIOANALYSIS | 2015年 / 7卷 / 18期

关键词：

BLOOD SPOT; REGULATED BIOANALYSIS; QUANTITATIVE BIOANALYSIS; EBF RECOMMENDATION; ONLINE DESORPTION; PLASMA SPOTS; DBS; HEMATOCRIT; QUANTIFICATION; PERSPECTIVES;

D O I：

10.4155/bio.15.166

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Microsampling, mainly as DBS, has been significantly expanded in the biomedical and pharmaceutical communities in the last 10 years. In parallel, technology and methodology have evolved to overcome some of the issues associated with this sampling procedure. Despite the continuous developments and interest, only a few validated and routinely implemented clinical applications have arisen beyond the initial inborn screening. Based on the latest developments in this field, this perspective aims to discuss some of the missing steps (i.e., the habits to change, the Health Authorities acceptance and the shift for dried plasma generation), which may turn the current use of microsampling into an established and standard procedure in clinical and pharmaceutical analysis.

引用

页码：2375 / 2385

页数：11

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