First total synthesis of four natural prenylated flavonoids

被引：6

作者：

Yang, Jin Hui ^{[1
]}

Zuo, Wu Biao ^{[1
]}

Guo, Dong Dong ^{[1
]}

Luo, Jun Shan ^{[1
]}

Huang, Wen Qian ^{[1
]}

机构：

[1] Ningxia Univ, State Key Lab Cultivat Base Nat Gas Convers, Yinchuan 750021, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2012年 / 23卷 / 12期

关键词：

Prenylated flavonoid; (+/-)-Abyssinone-VI-4-O-methyl ether; (+/-)-Abyssinone-IV-4 '-O-methyl ether; (+/-)-Abyssinone-V-4 '-O-methyl ether; (+/-)-Sigmoidin E; Total synthesis; ERYTHRINA; ANTIBACTERIAL; FLAVANONES;

D O I：

10.1016/j.cclet.2012.10.012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile approach for the first total synthesis of prenylated flavonoids, (+/-)-abyssinone-VI-4-O-methyl ether 1, (+/-)-abyssinone-IV-4'-O-methyl ether 2, (+/-)-abyssinone-V-4'-O-methyl ether 3 and (+/-)-sigmoidin E 4 has been described. The key intermediate 4-hydroxy-3,5-di-(3-methylbut-2-enyl)benzaldehyde 6 was also first synthesized that features regioselective prenylation of 4-hydroxybenzaldehyde and crystallizing with petroleum ether from the reaction mixture by freeze-out effect. (C) 2012 Jin Hui Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1375 / 1377

页数：3

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