Maternal Hypercholesterolemia May Involve in Preterm Birth

被引：3

作者：

Chen, Jingfei ^{[1
]}

Hua, Lan ^{[1
]}

Luo, Fei ^{[2
]}

Chen, Jianlin ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Obstet & Gynecol, Changsha, Peoples R China

[2] Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Med, Changsha, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷

基金：

中国国家自然科学基金;

关键词：

preterm birth; macrophage; cholesterol; low-density lipoprotein receptor; inflammation; CHOLESTEROL; MACROPHAGES; PREGNANCY; ATHEROSCLEROSIS; DYSLIPIDEMIA; INFLAMMATION; ABSENCE; TARGET; CELLS;

D O I：

10.3389/fcvm.2022.818202

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Maternal hypercholesterolemia during pregnancy is associated with an increased risk of preterm birth which is defined as <37 weeks of complete gestation. However, the underlying mechanism for the association between hypercholesterolemia and preterm birth is not fully understood. Macrophage, as one of the largest cell types in the placenta, plays a very critical role in mediating inflammation and triggers labor initiation. Here, we hypothesize that macrophages can uptake maternal excessive cholesterol leading to its accumulation, resulting in a breach of the immune tolerance and precipitating labor.

引用

页数：4

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