Molecular modeling of the pathways of vesicle-membrane interaction

被引：60
|
作者：
Yue, Tongtao [1 ,2 ]
Zhang, Xianren [2 ]
机构：
[1] China Univ Petr E China, State Key Lab Heavy Oil Proc, Ctr Bioengn & Biotechnol, Qingdao 266555, Peoples R China
[2] Beijing Univ Chem Technol, Div Mol & Mat Simulat, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China
来源：
SOFT MATTER | 2013年 / 9卷 / 02期
基金：
中国国家自然科学基金;
关键词：
RECEPTOR-MEDIATED ENDOCYTOSIS; LIPID-MEMBRANES; CELLULAR UPTAKE; NANOPARTICLES; DYNAMICS; FUSION; TRANSLOCATION; PENETRATION; MECHANICS; RUPTURE;
D O I：
10.1039/c2sm26940f
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this work we systematically investigate the pathways of the interaction between elastic vesicles and lipid membranes with the aid of computer simulation techniques. Different vesicle responses to the vesicle-membrane adhesion, including vesicle fusion, vesicle hemi-fusion, vesicle adhesion, vesicle endocytosis and vesicle rupture, are observed from our simulations. We also investigate how the pathways of vesicle-membrane interaction depend on the adhesion strength, and the membrane and vesicle properties.
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页码：559 / 569
页数：11
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