A convenient synthesis of chiral 1,2,4-oxadiazoles from N-protected (α-aminoacyl)benzotriazoles

被引：61
|
作者：
Katritzky, AR [1 ]
Shestopalov, AA [1 ]
Suzuki, K [1 ]
机构：
[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA
来源：
ARKIVOC | 2005年
关键词：
chiral 1,2,4-oxadiazole; N-aminoacylbenzotriazole; N-acylbenzotriazole; benzotriazole methodology;
D O I：
10.3998/ark.5550190.0006.705
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,2,4-Oxadiazoles (4a-k, 6a-c, 7a-d, and 11a-f) derived from chiral alpha-amino acids were synthesized in 70-94% yields via a fast and easy procedure under mild conditions. They were shown to be at least 97% enantiomerically pure by HPLC and NMR.
引用
收藏
页码：36 / 55
页数：20
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