The Efficacy of Tadalafil Daily vs on Demand in the Treatment of Erectile Dysfunction: A Systematic Review and Meta-analysis

被引:13
作者
Bansal, Utsav K. [1 ]
Jones, Cameron
Fuller, Thomas W.
Wessel, Charles
Jackman, Stephen V.
机构
[1] Univ Pittsburgh, Sch Med, 3550 Terrace St, Pittsburgh, PA 15213 USA
关键词
ONCE-A-DAY; RANDOMIZED OPEN-LABEL; 20; MG; INTERNATIONAL INDEX; VS; TADALAFIL; MEN; SILDENAFIL; SAFETY; GUIDELINES; OUTCOMES;
D O I
10.1016/j.urology.2017.08.031
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
We present a review comparing the use of tadalafil daily vs on-demand for erectile dysfunction. We examined randomized controlled trials and observational studies that examined the use of tadalafil for at least 8 weeks of follow-up with the primary outcome of International Index for Erectile Dysfunction-Erectile Function domain. Eight studies that examined the desired dosing regimens were identified. Of these, 6 studies included the primary end point of 12 weeks. Those patients taking tadalafil daily for 12 weeks scored on average 1.82 points higher in International Index for Erectile Dysfunction-Erectile Function domain scores, although the difference may not be clinically significant (Fig. 1). (C) 2017 Elsevier Inc.
引用
收藏
页码:6 / 11
页数:6
相关论文
共 34 条
[31]   A Randomized Open-Label Trial with a Crossover Comparison of Sexual Self-Confidence and Other Treatment Outcomes Following Tadalafil Once a Day Vs. Tadalafil or Sildenafil On-Demand in Men with Erectile Dysfunction [J].
Rubio-Aurioles, Eusebio ;
Porst, Hartmut ;
Kim, Edward D. ;
Montorsi, Francesco ;
Hackett, Geoff ;
Martin Morales, Antonio ;
Stuckey, Bronwyn ;
Buttner, Hartwig ;
West, Teena M. ;
Huynh, Ngan N. ;
Lenero, Enrique ;
Burns, Patrick ;
Kopernicky, Vladimir .
JOURNAL OF SEXUAL MEDICINE, 2012, 9 (05) :1418-1429
[32]   Prevalence and risk factors for erectile dysfunction in the US [J].
Selvin, Elizabeth ;
Burnett, Arthur L. ;
Platz, Elizabeth A. .
AMERICAN JOURNAL OF MEDICINE, 2007, 120 (02) :151-157
[33]   Efficacy and treatment satisfaction with on-demand tadalafil (Cialis®) in men with erectile dysfunction [J].
Skoumal, R ;
Chen, JZ ;
Kula, K ;
Breza, J ;
Calomfirescu, N ;
Basson, BR ;
Kopernicky, V .
EUROPEAN UROLOGY, 2004, 46 (03) :362-369
[34]  
Washington SL, 2010, DRUG DES DEV THER, V4, P159