Genetic polymorphisms and multifactorial diseases: facts and fallacies revealed by the glucocorticoid receptor gene

被引：46

作者：

van Rossum, EFC ^{[1
]}

Russcher, L ^{[1
]}

Lamberts, SWJ ^{[1
]}

机构：

[1] Erasmus MC, Dept Internal Med, NL-3015 GD Rotterdam, Netherlands

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2005年 / 16卷 / 10期

关键词：

D O I：

10.1016/j.tem.2005.10.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In recent years enormous progress in determining the sequence of the human genome has led to a rapid development of research into polymorphisms in genes involved in complex diseases. It is clear, however, that there are important limitations in many of these association studies. Problems with reliable and reproducable phenotyping, the number of individuals studied, racial heterogeneity, population stratification (founder effect), functionality and multiple testing often mean that studies are not reproducible. In this review we describe a number of the limitations related to this type of research; from both our own experience with studies on polymorphisms in the glucocorticoid receptor gene, and shortcomings and solutions from the literature.

引用

页码：445 / 450

页数：6

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