Mesenchymal stem cell-derived exosomes as a bioinspired nanoscale tool toward next-generation cell-free treatment

被引:7
作者
Asadi, Khatereh [1 ,2 ]
Amini, Abbas [3 ,4 ]
Gholami, Ahmad [5 ,6 ,7 ]
机构
[1] Shiraz Univ Med Sci, Biotechnol Res Ctr, Shiraz, Iran
[2] Guilan Univ Med Sci, Guilan Rd Trauma Res Ctr, Rasht, Iran
[3] Australian Univ Kuwait, Dept Mech Engn, Kuwait 13015, Kuwait
[4] Western Sydney Univ, Ctr Infrastruct Engn, Kingswood, NSW, Australia
[5] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran
[6] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Dept Med Nanotechnol, Shiraz, Iran
[7] Shiraz Univ Med Sci, POB 71345-1583, Shiraz, Iran
关键词
Mesenchymal stem cell; Exosome; Isolation; Fabrication; Cargo loading; DRUG-DELIVERY;
D O I
10.1016/j.jddst.2022.103856
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Mesenchymal stem cells derived exosomes (MSCs-exosomes) with intrinsic dominance bioinspired nanoscale tools to produce efficient biological compounds based on nanotechnology and biotechnology combinations for clinical use.Main text: MSCs-exosomes with the vesicular bilayer structure are enriched with many proteins, nucleic acids, and lipids that modulate a wide range of biological phenomena and provide various substances for incorporation. Novel modification approaches look viable to assess their target site delivery, intracellular communications, and half-life. Various endeavors have been made to develop efficient production, purification, and functionalization techniques as a straightforward avenue to achieve effective targeted delivery. Moreover, the progress of standard analytical tools could bring exosome products from the bench to the bedside. Furthermore, MSCs-exosomes are expected to be the next generation of cell-free treatments applied to most human pathologic conditions.Conclusion: MSCs-exosomes encompass parental cells' crucial paracrine functions instead of using cells as therapeutic agents. This review mentioned all aspects of MSCs-exosomes isolation, encapsulation, modification strategies, regulations, and the recent research progress in various diseases of MSC-exosomes.
引用
收藏
页数:13
相关论文
共 92 条
[1]   Natural vs. Synthetic Phosphate as Efficient Heterogeneous Compounds for Synthesis of Quinoxalines [J].
Amini, Abbas ;
Fallah, Azadeh ;
Sedaghat, Ahmad ;
Gholami, Ahmad ;
Cheng, Chun ;
Gupta, Anju R. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (24)
[2]   Virosome-based nanovaccines; a promising bioinspiration and biomimetic approach for preventing viral diseases: A review [J].
Asadi, Khatereh ;
Gholami, Ahmad .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 182 :648-658
[3]   Retinoic acid -loaded core-shell fibrous scaffold for neuronal differentiation of trabecular mesenchymal stem cells [J].
Asadi, Khatereh ;
Mortazavi, Yousef ;
Nadri, Samad .
NANOMEDICINE JOURNAL, 2021, 8 (01) :73-79
[4]   Exosomal miRNAs in hepatitis B virus related liver disease: a new hope for biomarker [J].
Bandopadhyay, Manikankana ;
Bharadwaj, Mausumi .
GUT PATHOGENS, 2020, 12 (01)
[5]   International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19 [J].
Boerger, Verena ;
Weiss, Daniel J. ;
Anderson, Johnathon D. ;
Borras, Francesc E. ;
Bussolati, Benedetta ;
Carter, David R. F. ;
Dominici, Massimo ;
Falcon-Perez, Juan M. ;
Gimona, Mario ;
Hill, Andrew F. ;
Hoffman, Andrew M. ;
Kleijn, Dominique de ;
Levine, Bruce L. ;
Lim, Rebecca ;
Lotvall, Jan ;
Mitsialis, S. Alex ;
Monguio-Tortajada, Marta ;
Muraca, Maurizio ;
Nieuwland, Rienk ;
Nowocin, Anna ;
O'Driscoll, Lorraine ;
Ortiz, Luis A. ;
Phinney, Donald G. ;
Reischl, Ilona ;
Rohde, Eva ;
Sanzenbacher, Ralf ;
Thery, Clotilde ;
Toh, Wei Seong ;
Witwer, Kenneth W. ;
Lim, Sai Kiang ;
Giebel, Bernd .
CYTOTHERAPY, 2020, 22 (09) :482-485
[6]   Exosomes in bodily fluids are a highly stable resource of disease biomarkers [J].
Boukouris, Stephanie ;
Mathivanan, Suresh .
PROTEOMICS CLINICAL APPLICATIONS, 2015, 9 (3-4) :358-367
[7]   A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum [J].
Brennan, K. ;
Martin, K. ;
FitzGerald, S. P. ;
O'Sullivan, J. ;
Wu, Y. ;
Blanco, A. ;
Richardson, C. ;
Mc Gee, M. M. .
SCIENTIFIC REPORTS, 2020, 10 (01)
[8]   Clinical Tracking of Cell Transfer and Cell Transplantation: Trials and Tribulations [J].
Bulte, Jeff W. M. ;
Daldrup-Link, Heike E. .
RADIOLOGY, 2018, 289 (03) :604-615
[9]   Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes [J].
Busato, Alice ;
Bonafede, Roberta ;
Bontempi, Pietro ;
Scambi, Ilaria ;
Schiaffino, Lorenzo ;
Benati, Donatella ;
Malatesta, Manuela ;
Sbarbati, Andrea ;
Marzola, Pasquina ;
Mariotti, Raffaella .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016, 11 :2481-2490
[10]   RETRACTED: Mesenchymal stem cell-derived exosome miR-542-3p suppresses inflammation and prevents cerebral infarction (Retracted Article) [J].
Cai, Guofeng ;
Cai, Guoliang ;
Zhou, Haichun ;
Zhuang, Zhe ;
Liu, Kai ;
Pei, Siying ;
Wang, Yanan ;
Wang, Hong ;
Wang, Xin ;
Xu, Shengnan ;
Cui, Cheng ;
Sun, Manchao ;
Guo, Sihui ;
Jia, Kunping ;
Wang, Xiuzhen ;
Zhang, Dianquan .
STEM CELL RESEARCH & THERAPY, 2021, 12 (01)