Beyond receptor expression levels: The relevance of target accessibility in ligand-directed pharmacodelivery systems
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作者:
Ozawa, Michael G.
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机构:Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Ozawa, Michael G.
Zurita, Amado J.
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机构:Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Zurita, Amado J.
Dias-Neto, Emmanuel
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机构:Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Dias-Neto, Emmanuel
Nunes, Diana N.
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机构:Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Nunes, Diana N.
Sidman, Richard L.
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机构:
Harvard Univ, Sch Med, Boston, MA 02115 USA
Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02115 USAUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Sidman, Richard L.
[3
,4
]
Gelovani, Juri G.
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Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Gelovani, Juri G.
[2
]
Arap, Wadih
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Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Arap, Wadih
[1
]
Pasqualini, Renata
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Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Pasqualini, Renata
[1
]
机构:
[1] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77030 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
[4] Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02115 USA
For development of a new ligand-directed pharmacology, it is critical to measure delivery of targeted drug ligands via molecular imaging or diagnostic readouts (termed theranostics). Combinatorial peptide libraries serve as unbiased functional screens that can identify specific peptides targeting cell-surface receptors accessible to the circulation. As candidate drug leads, such peptides provide motifs likely to modify ligand-receptor interactions and downstream signal transduction pathways. This strategy is synergistic with genomic and proteomic approaches and has yielded insights into the specialized nature of the target tissue microenvironment. However, for this vision to be realized, one must look, as recent literature suggests, beyond receptor levels and critically analyze ligand accessibility as a key determinant in pharmacodelivery systems.
机构:
Kyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, JapanKyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan
Yamaura, Kei
Kuwata, Keiko
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Nagoya Univ, Inst Transformat Biomol ITbM, Chikusa Ku, Nagoya, Aichi 4648602, JapanKyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan
Kuwata, Keiko
Tamura, Tomonori
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Kyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, JapanKyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan
Tamura, Tomonori
Kioi, Yoshiyuki
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Kyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, JapanKyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan
Kioi, Yoshiyuki
Takaoka, Yousuke
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Kyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, JapanKyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan
Takaoka, Yousuke
Kiyonaka, Shigeki
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Kyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, JapanKyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan
Kiyonaka, Shigeki
Hamachi, Itaru
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Kyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan
Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Chiyoda Ku, Tokyo 1020075, JapanKyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan
机构:
Univ New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Div Mol Med, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Dept Internal Med, Albuquerque, NM 87131 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Cardo-Vila, Marina
Marchio, Serena
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Univ New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Div Mol Med, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Dept Internal Med, Albuquerque, NM 87131 USA
Univ Turin, Dept Oncol, Turin, Italy
IRCCS, Candiolo Canc Inst, Candiolo, ItalyUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Marchio, Serena
Sato, Masanori
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Hamamatsu Univ Sch Med, Dept Surg 1, Hamamatsu, Shizuoka, JapanUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Sato, Masanori
Staquicini, Fernanda I.
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Univ New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Div Mol Med, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Dept Internal Med, Albuquerque, NM 87131 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Staquicini, Fernanda I.
Smith, Tracey L.
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Univ New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Div Mol Med, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Dept Internal Med, Albuquerque, NM 87131 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Smith, Tracey L.
Bronk, Julianna K.
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Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Bronk, Julianna K.
Yin, Guosheng
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Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Yin, Guosheng
Zurita, Amado J.
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Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Zurita, Amado J.
Sun, Menghong
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Fudan Univ, Shanghai Canc Ctr, Tissue Bank, Shanghai, Peoples R China
Fudan Univ, Shanghai Canc Ctr, Dept Pathol, Shanghai, Peoples R ChinaUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Sun, Menghong
Behrens, Carmen
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Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Behrens, Carmen
Sidmari, Richard L.
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Harvard Med Sch, Dept Neurol, Boston, MA USA
Beth Israel Deaconess Med Ctr, Boston, MA 02215 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Sidmari, Richard L.
Lee, J. Jack
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Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Lee, J. Jack
Hong, Waun K.
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Univ Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Hong, Waun K.
Wistuba, Ignacio I.
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Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Wistuba, Ignacio I.
Arap, Wadih
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Univ New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Div Mol Med, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Div Hematol Oncol, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Dept Internal Med, Albuquerque, NM 87131 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Arap, Wadih
Pasqualini, Renata
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机构:
Univ New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Div Mol Med, Albuquerque, NM 87131 USA
Univ New Mexico, Sch Med, Dept Internal Med, Albuquerque, NM 87131 USAUniv New Mexico, Ctr Comprehens Canc, Albuquerque, NM 87131 USA
Pasqualini, Renata
AMERICAN JOURNAL OF PATHOLOGY,
2016,
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: 2162
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